[卡铂和顺丙铂对裸鼠体内人膀胱癌和前列腺癌的抗肿瘤作用]
[Antitumor effect of carboplatin and iproplatin on human urinary bladder and prostatic cancers grown in nude mice].
作者信息
Hasegawa J, Kawamura N, Yamada S, Tsuboi N, Akimoto M
机构信息
Dept. of Urology, Nippon Medical School, Tokyo.
出版信息
Gan To Kagaku Ryoho. 1987 Dec;14(12):3279-83.
Antitumor effects of carboplatin and iproplatin, a second-generation cisplatin analog were studied using cisplatin sensitive human urinary bladder (NM-B-1) and prostatic cancers (PRO-1) grown in nude mice. Both NM-B-1 and PRO-1 were sensitive to carboplatin and iproplatin. The tumor-regression effect of carboplatin at the fourfold dose of cisplatin was comparable to that of cisplatin. Iproplatin at the eight to sixteen times dose of cisplatin showed a comparable tumor regression to cisplatin. The range of effective dose was wider in carboplatin than cisplatin and that of iproplatin was not so wide as cisplatin.
使用在裸鼠体内生长的顺铂敏感型人膀胱癌（NM-B-1）和前列腺癌（PRO-1）研究了第二代顺铂类似物卡铂和异丙铂的抗肿瘤作用。NM-B-1和PRO-1对卡铂和异丙铂均敏感。卡铂四倍剂量时的肿瘤消退效果与顺铂相当。异丙铂八至十六倍剂量时显示出与顺铂相当的肿瘤消退效果。卡铂的有效剂量范围比顺铂宽，而异丙铂的有效剂量范围不如顺铂宽。
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