不稳定型心绞痛患者 、 、 、 、 和 基因多态性。
Polymorphisms in , , , , , and Genes in Patients with Unstable Angina.
机构信息
Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.
出版信息
Int J Environ Res Public Health. 2020 Oct 15;17(20):7506. doi: 10.3390/ijerph17207506.
INTRODUCTION
Coronary artery disease (CAD) is a significant public health problem because it is one of the major causes of death worldwide. Several studies have investigated the associations between CAD and polymorphisms in genes connected with platelet aggregation and the risk of venous thromboembolism.
AIM
In this study, we examined the associations between polymorphisms in (rs1671152), (rs12566888), (rs7940646), (rs342286), (rs10761741), (rs2363910), and CAD in the form of unstable angina as well as selected clinical and biochemical parameters. The study enrolled 246 patients with diagnosed unstable angina and 189 healthy controls.
RESULTS
There were no significant differences in the distribution of the studied polymorphisms between the patients with unstable angina and the controls. In patients with the rs1671152 GG genotype, we observed increased BMI values and an increased frequency of type 2 diabetes diagnosis.
CONCLUSIONS
The results of this study suggest a lack of association between (rs1671152), (rs12566888), (rs7940646), (rs342286), (rs10761741), (rs2363910), and unstable angina. The results indicate an association between (rs1671152) and type 2 diabetes.
简介
冠心病（CAD）是一个重大的公共卫生问题，因为它是全球主要死亡原因之一。多项研究调查了 CAD 与与血小板聚集和静脉血栓栓塞风险相关的基因多态性之间的关联。
目的
在这项研究中，我们研究了 （rs1671152）、 （rs12566888）、 （rs7940646）、 （rs342286）、 （rs10761741）、 （rs2363910）等基因多态性与不稳定型心绞痛之间的关联，以及选择的临床和生化参数。该研究纳入了 246 例确诊为不稳定型心绞痛的患者和 189 名健康对照者。
结果
不稳定型心绞痛患者与对照组之间，研究中多态性的分布无显著差异。在不稳定型心绞痛患者中，携带 rs1671152 GG 基因型的患者，体重指数（BMI）值较高，2 型糖尿病的诊断频率较高。
结论
本研究结果提示， （rs1671152）、 （rs12566888）、 （rs7940646）、 （rs342286）、 （rs10761741）、 （rs2363910）与不稳定型心绞痛之间不存在关联。结果提示 （rs1671152）与 2 型糖尿病之间存在关联。
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