Istanbul University-Cerrahpasa, Faculty of Engineering, Department of Chemistry, 34320 Avcilar, Istanbul, Turkey.
Curr Med Chem. 2021;28(18):3490-3513. doi: 10.2174/0929867327666201019143647.
The usage of dendrimers or cascade molecules in the biomedical area has recently attracted much attention worldwide. Furthermore, dendrimers are interesting in clinical and pre-clinical applications due to their unique characteristics. Cancer is one of the most widespread challenges and important diseases, which has the highest mortality rate. In this review, the recent advances and developments (from 2009 up to 2019) in the field of electrochemical and electroluminescence immunosensors for detection of the cancer markers are presented. Moreover, this review covers the basic fabrication principles and types of electrochemical and electrochemiluminescence dendrimer-based immunosensors. In this review, we have categorized the current dendrimer based-electrochemical/ electroluminescence immunosensors into five groups: dendrimer/ magnetic particles, dendrimer/ferrocene, dendrimer/metal nanoparticles, thiol-containing dendrimer, and dendrimer/quantum dots based-immunosensors.
树状大分子或级联分子在生物医学领域的应用最近引起了全世界的广泛关注。此外，由于其独特的特性，树状大分子在临床前和临床应用中具有很大的吸引力。癌症是最常见的挑战和重要疾病之一，其死亡率最高。在这篇综述中，介绍了电化学和电致发光免疫传感器领域在检测癌症标志物方面的最新进展和发展（截至 2009 年至 2019 年）。此外，本综述还涵盖了电化学和基于树突状大分子的电致化学发光免疫传感器的基本制造原理和类型。在这篇综述中，我们将基于树突状大分子的电化学/电致化学发光免疫传感器分为五类：树突状大分子/磁性粒子、树突状大分子/二茂铁、树突状大分子/金属纳米粒子、含硫醇树突状大分子和树突状大分子/量子点基于免疫传感器。
