癌症患者 dynapenia 的存在及其与人体测量学变量的关联。
Presence of dynapenia and association with anthropometric variables in cancer patients.
机构信息
Nutrition Course. Department of Integrated Health Education, Federal University of Espirito Santo, Vitoria, Espırito Santo, Brazil. Marechal Campos avenue, 1468 - Maruípe, Vitória, Espírito Santo, CEP: 29040-090, Brazil.
University Cassiano Antonio Moraes Hospital, Vitoria, Espırito Santo, Brazil. Marechal Campos avenue, 1355 - Santa Cecília, Vitória, Espírito Santo, CEP: 29043-260, Brazil.
出版信息
BMC Cancer. 2020 Oct 19;20(1):1010. doi: 10.1186/s12885-020-07519-4.
BACKGROUND
Dynapenia is defined as an age-related loss of muscle strength. There is little information on dynapenia in cancer patients and on how it relates to anthropometric variables. The aim of this study was to analyze the presence of dynapenia and its association with anthropometric variables in hospitalized cancer patients.
METHODS
Participants comprised adult and elderly cancer patients evaluated within the first 48 h of hospital admission to a tertiary public hospital, a referral center for gastrointestinal tract surgery. Anthropometric variables were measured according to standardized protocols. Dynapenia was identified based on handgrip strength (HGS), according to the cutoff points defined by the European Working Group on Sarcopenia in Older People (EWGSOP2), with values for women < 16 kg and for men < 27 kg. Statistical analysis was performed using SPSS software, version 22.0, with a significance level of 5%.
RESULTS
This study included 158 patients aged in average 59.5 ± 14.0 years; of these, 53.6% were elderly, 58.9% non-white and 59.5% had some degree of malnutrition. The most prevalent type of cancer was that of the lower gastrointestinal tract (33.5%). The presence of dynapenia was observed in 23.4% of the patients and cachexia in 36.1%. There was an association between dynapenia with age (p < 0.001), life stage (p = 0.002) and race/color (p = 0.027), and also with body mass index (BMI) (p = 0.001) and adductor pollicis muscle thickness (APMT) of both hands (p < 0.05). After logistic regression analysis, adjusted for the sociodemographic variables, the APMT of the dominant hand and the low weight determined by body mass index remained associated with the occurrence of dynapenia (p < 0.05).
CONCLUSIONS
In this study we confirmed that dynapenia was present in cancer patients, being associated with APMT of the dominant hand and low weight. HSG was proven to be a reliable and complementary measure to be added to the process of assessing nutritional status, contributing to the nutritional diagnosis of these patients and to the detection of early muscle depletion.
背景
动力不足被定义为与年龄相关的肌肉力量丧失。关于癌症患者的动力不足以及它与人体测量变量的关系的信息很少。本研究的目的是分析住院癌症患者中动力不足的存在及其与人体测量变量的关系。
方法
参与者为在一家三级公立医院住院的成年和老年癌症患者，该医院是胃肠道手术的转诊中心。根据标准化方案测量人体测量变量。根据欧洲老年人肌肉减少症工作组（EWGSOP2）定义的截断点，通过握力（HGS）确定动力不足，女性<16kg，男性<27kg。使用 SPSS 软件版本 22.0 进行统计分析，显著性水平为 5%。
结果
本研究包括 158 名平均年龄 59.5±14.0 岁的患者；其中 53.6%为老年人，58.9%为非白人，59.5%有一定程度的营养不良。最常见的癌症类型是下消化道癌症（33.5%）。23.4%的患者存在动力不足，36.1%的患者存在恶病质。动力不足与年龄（p<0.001）、生命阶段（p=0.002）和种族/肤色（p=0.027）有关，与体重指数（BMI）（p=0.001）和双手内收拇指肌厚度（APMT）（p<0.05）有关。在调整社会人口统计学变量后进行逻辑回归分析，优势手的 APMT 和 BMI 确定的低体重与动力不足的发生相关（p<0.05）。
结论
在这项研究中，我们证实了癌症患者存在动力不足，与优势手的 APMT 和低体重有关。HGS 被证明是一种可靠且互补的措施，可以添加到评估营养状况的过程中，有助于这些患者的营养诊断和早期肌肉消耗的检测。
Zotero 插件