Department of Integrated Education, Federal University of Espirito Santo, Vitoria, Espírito Santo, Brazil.
University Cassiano Antônio Moraes Hospital, Vitória, Espírito Santo, Brazil.
PLoS One. 2019 Aug 2;14(8):e0220334. doi: 10.1371/journal.pone.0220334. eCollection 2019.
Malnutrition is common in patients with cancer, and its early diagnosis can reduce or prevent further complications and improve the clinical and nutritional prognosis. Adductor Pollicis Muscle Thickness (APMT) and Handgrip Strength have been explored in this population to identify a reduction in strength and muscle mass prior to the use of conventional methods. We aimed to correlate APMT and Handgrip Strength with conventional anthropometric variables in cancer patients and verify their association with nutritional status as determined by the Patient-Generated Subjective Global Assessment (PG-SGA).
A cross-sectional study was conducted with 80 patients diagnosed with cancer who were candidates for surgery. Nutritional status was obtained from the PG-SGA. Conventional anthropometric measurements were taken, as well as APMT and Handgrip Strength. Pearson's correlation analysis and multivariate linear regression were applied to detect the influence of variables on APMT and HGS. A significance level of 5.0% was considered.
A high prevalence of malnutrition and the need for dietotherapic intervention was found, identified by the PG-SGA. Correlations between APMT and Handgrip Strength with anthropometric variables and with the PG-SGA score were observed. After regression adjustments, the variables that interacted with APMT were TSF and AC, and the PG-SGA score, corrected Muscle Arm Area (CAMA), and age interacted with Handgrip Strength.
Correlations between anthropometric measurements and the PG-SGA score with APMT and Handgrip Strength were observed, even after adjusting for age and sex. These associations demonstrate that APMT and Handgrip Strength can be used with criterion in patients with cancer as complementary methods to evaluate nutritional risk and the need for nutritional intervention.
癌症患者中普遍存在营养不良的情况，早期诊断可以减少或预防进一步的并发症，并改善临床和营养预后。人们已经探索了拇内收肌厚度（APMT）和手握力在该人群中的作用，以在使用常规方法之前识别力量和肌肉质量的下降。我们旨在将 APMT 和手握力与癌症患者的常规人体测量变量相关联，并验证它们与患者生成的主观整体评估（PG-SGA）确定的营养状况的相关性。
进行了一项横断面研究，纳入了 80 名被诊断患有癌症并适合手术的患者。通过 PG-SGA 获得营养状况。进行了常规人体测量测量，以及 APMT 和手握力测量。应用 Pearson 相关分析和多元线性回归来检测变量对 APMT 和 HGS 的影响。采用 5.0%的显著性水平。
PG-SGA 发现，癌症患者存在较高的营养不良发生率和需要进行饮食治疗的干预。观察到 APMT 和手握力与人体测量变量以及与 PG-SGA 评分之间的相关性。经过回归调整后，与 APMT 相互作用的变量是 TSF 和 AC，PG-SGA 评分、校正肌肉臂区（CAMA）和年龄与手握力相互作用。
即使在调整了年龄和性别后，也观察到人体测量测量值与 PG-SGA 评分与 APMT 和手握力之间的相关性。这些关联表明，APMT 和手握力可以与标准一起用于癌症患者，作为评估营养风险和营养干预需求的补充方法。
