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系统评价和网络荟萃分析随机对照试验议定书,旨在评估早期养育干预预防儿童和青少年内化问题的有效性。

Protocol for a systematic review and network meta-analysis of randomised controlled trials examining the effectiveness of early parenting interventions in preventing internalising problems in children and adolescents.

机构信息

Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BP, UK.

Department of Basic Psychology & Methodology, University of Murcia, Murcia, Spain.

出版信息

Syst Rev. 2020 Oct 19;9(1):244. doi: 10.1186/s13643-020-01500-9.

DOI:10.1186/s13643-020-01500-9
PMID:33076982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7574314/
Abstract

BACKGROUND

Internalising problems, such as depression and anxiety, are common and represent an important economical and societal burden. The effectiveness of parenting interventions in reducing the risk of internalising problems in children and adolescents has not yet been summarised. The aims of this review are to assess the effectiveness of parenting interventions in the primary, secondary and tertiary prevention of internalising problems in children and adolescents and to determine which intervention components and which intervention aspects are most effective for reducing the risk of internalising problems in children and adolescents.

METHODS

Electronic searches in OVID SP versions of MEDLINE, EMBASE and PsycINFO; Cochrane Central Register of Controlled Trials; EBSCO version of ERIC and ClinicalTrials.gov have been performed to identify randomised controlled trials or quasi-randomised controlled trials of parenting interventions. At least two independent researchers will assess studies for inclusion and extract data from each paper. The risk of bias assessment will be conducted independently by two reviewers using the Cochrane Collaboration's Risk of Bias Assessment Tool. Statistical heterogeneity is anticipated given potential variation in participant characteristics, intervention type and mode of delivery, and outcome measures. Random effects models, assuming a common between-study variability, will be used to account for statistical heterogeneity. Results will be analysed using a network meta-analysis (NMA). If appropriate, we will also conduct a component-level NMA, where the 'active ingredients' of interventions are modelled using a network meta-regression approach.

DISCUSSION

Preventing and reducing internalising problems could have major beneficial effects at the economic and societal level. Informing policy makers on the effectiveness of parenting interventions and on which intervention's component is driving the effect is important for the development of treatment strategies.

SYSTEMATIC REVIEW REGISTRATION

International Prospective Register for Systematic Reviews (PROSPERO) number CRD42020172251.

摘要

背景

内化问题,如抑郁和焦虑,较为常见,且代表着重要的经济和社会负担。育儿干预在降低儿童和青少年内化问题风险方面的有效性尚未得到总结。本综述旨在评估育儿干预在儿童和青少年内化问题的一级、二级和三级预防中的有效性,并确定哪些干预组成部分和干预方面对降低儿童和青少年内化问题的风险最有效。

方法

在 OVID SP 版本的 MEDLINE、EMBASE 和 PsycINFO、Cochrane 对照试验中心注册库、EBSCO 版 ERIC 和 ClinicalTrials.gov 中进行电子检索,以确定育儿干预的随机对照试验或准随机对照试验。至少两名独立研究人员将评估研究纳入情况并从每篇论文中提取数据。两名评审员将独立使用 Cochrane 协作风险偏倚评估工具评估研究的风险偏倚。鉴于参与者特征、干预类型和交付模式以及结果测量的潜在差异,预计会存在统计异质性。将使用随机效应模型(假设研究之间存在共同的变异性)来解释统计异质性。结果将使用网络荟萃分析(NMA)进行分析。如果合适,我们还将进行组件级 NMA,其中使用网络荟萃回归方法对干预的“有效成分”进行建模。

讨论

预防和减少内化问题可能会对经济和社会层面产生重大积极影响。告知政策制定者育儿干预的有效性以及哪种干预组成部分在产生效果方面很重要,这对于制定治疗策略很重要。

系统评价注册

国际前瞻性系统评价登记处(PROSPERO)编号 CRD42020172251。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39c2/7574314/57c539637d15/13643_2020_1500_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39c2/7574314/153a214bcd24/13643_2020_1500_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39c2/7574314/c972623c381d/13643_2020_1500_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39c2/7574314/57c539637d15/13643_2020_1500_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39c2/7574314/153a214bcd24/13643_2020_1500_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39c2/7574314/b2160931f653/13643_2020_1500_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39c2/7574314/00761bdd75d9/13643_2020_1500_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39c2/7574314/c972623c381d/13643_2020_1500_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39c2/7574314/57c539637d15/13643_2020_1500_Fig5_HTML.jpg

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