Pratt B M, Woolfenden S R
Psychological Medicine, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, Australia, 2145.
Cochrane Database Syst Rev. 2002;2002(2):CD002891. doi: 10.1002/14651858.CD002891.
Eating disorders represent an extremely difficult condition to treat and patients consume an enormous amount of mental health energy and resources. Being young, female, and dieting are some of the few identified risk factors that have been reliably linked to the development of eating disorders, and several prevention eating disorder prevention programs have been developed and trialed with children and adolescents. The purpose of this systematic review is to evaluate the effectiveness of eating disorder prevention programs for children and adolescents both in the general population and those determined to be at risk.
Relevant trials are identified through searching the Cochrane Controlled Trial Register (CCTR) and relevant biomedical and social science databases. All terms necessary to detect prevention programs and the participant groups are used. A strategy to locate randomised controlled trials is used. Other sources of information are the bibliographies of systematic and non-systematic reviews and reference lists from articles identified through the search strategy. In order to identify unpublished studies, experts in the field are contacted by letter and/or electronic mail.
Randomised controlled trials (RCT) with a major focus on eating disorder prevention programs for children and adolescents, where there is no known DSM-IV diagnosis of an eating disorder, are eligible for inclusion in the review. Trials must include a control group and at least one objective outcome measure (eg. BMI) or a standardised psychological measure used with the intervention and control group, pre- and post-intervention.
A total of 1379 titles have been identified through the search to date. 13 studies were located that reported use of a randomised controlled trial methodology and were critically appraised by two independent reviewers. Five (5) studies were excluded as data were not reported in a useable form or useable data could not be obtained from the trial authors, one dissertation could not be obtained, one study had no "true" no-treatment or usual treatment control group, and one study did not use a pre-test outcome measure. Eight (8) studies met the selection criteria outlined above.
Only one of eight pooled comparisons of two or more studies using similar outcome measures and similar intervention types demonstrated the statistically significant effect of a particular type of eating disorder prevention program for children and adolescents. Combined data from two eating disorder prevention programs based on a media literacy and advocacy approach indicate a reduction in the internalisation or acceptance of societal ideals relating to appearance at a 3- to 6-month follow-up (Kusel, unpublished; Neumark-Sztainer2000) [SMD -0.28, -0.51 to -0.05, 95% CI]. However, there is insufficient evidence to conclude that this approach also demonstrated a significant impact on awareness of societal standards relating to appearance. There is insufficient evidence to support the effect of four programs designed to address eating attitudes and behaviours and other adolescent issues on body weight, eating disorder symptoms, associated eating disorder psychopathology or general psychological and physical well-being in the general sample or those classified as being at high risk for eating disorder (Buddeberg-F 1998; Killen 1993/1996; Santonastaso 1999; Zanetti 1999). Given only one program used a psychoeducation approach to prevent bulimia nervosa (Jerome, unpublished) and only one program adopted a focus on self-esteem (O'Dea 2000), the effect of these approaches could not be evaluated via meta-analyses. In relation to potential harmful effects, there is not sufficient evidence to suggest that harm resulted from any of the prevention programs included in the review.
REVIEWER'S CONCLUSIONS: The one significant pooled effect in the current review does not allow for any firm conclusions to be made about the impact of prevention programs for eating disorders in children and adolescents, although none of the pooled comparisons indicated evidence of harm. From a clinical perspective, the development and refinement of prevention programs is complicated by a lack of knowledge about risk factors associated with eating disorders and the need to strike a balance between delivering preventive interventions for eating disorders and considering the potential to cause harm. From a research perspective, the idea of "thresholds" for identifying young people at risk of developing eating disorders has been raised, and denial of concern or denial of illness represents a further issue complicating early identification in relation to eating disorder symptomatology. Longer-term effects of the intervention approaches will need to be monitored across development in order to demonstrate a decline in the incidence of eating disorders and associated risk factors.
饮食失调是一种极难治疗的疾病,患者会消耗大量的心理健康能量和资源。年轻、女性和节食是少数已被可靠地证明与饮食失调发展相关的风险因素,并且已经针对儿童和青少年开发并试验了几种饮食失调预防项目。本系统评价的目的是评估饮食失调预防项目对普通人群以及被确定为有风险的儿童和青少年的有效性。
通过检索Cochrane对照试验注册库(CCTR)以及相关的生物医学和社会科学数据库来识别相关试验。使用检测预防项目和参与人群所需的所有术语。采用一种定位随机对照试验的策略。其他信息来源包括系统评价和非系统评价的参考文献以及通过检索策略确定的文章的参考文献列表。为了识别未发表的研究,通过信函和/或电子邮件联系该领域的专家。
主要关注针对儿童和青少年饮食失调预防项目的随机对照试验(RCT),其中没有已知的DSM-IV诊断的饮食失调症,符合纳入本评价的条件。试验必须包括一个对照组以及至少一项客观结局测量指标(如BMI)或在干预组和对照组干预前后使用的标准化心理测量指标。
截至目前,通过检索共识别出1379个标题。找到13项报告使用随机对照试验方法的研究,并由两名独立评审员进行严格评估。排除了5项研究,原因是数据未以可用形式报告或无法从试验作者处获得可用数据,一项论文无法获取,一项研究没有“真正的”无治疗或常规治疗对照组,一项研究未使用预测试结局测量指标。8项研究符合上述选择标准。
在使用相似结局测量指标和相似干预类型的八项两项或更多研究的合并比较中,只有一项显示了特定类型的儿童和青少年饮食失调预防项目具有统计学显著效果。基于媒体素养和宣传方法的两项饮食失调预防项目的合并数据表明,在3至6个月的随访中,与外表相关的社会理想的内化或接受程度有所降低(库塞尔,未发表;纽马克 - 施泰纳2000年)[标准化均数差 -0.28,-0.51至 -0.05,95%置信区间]。然而,没有足够的证据得出该方法对外表相关社会标准的认知也有显著影响的结论。没有足够的证据支持四项旨在解决饮食态度和行为以及其他青少年问题的项目对一般样本或被归类为饮食失调高风险人群的体重、饮食失调症状、相关饮食失调精神病理学或总体心理和身体健康产生影响(布德贝格 - F 1998年;基伦1993/1996年;桑托纳斯塔索1999年;扎内蒂1999年)。由于只有一项项目采用心理教育方法预防神经性贪食症(杰罗姆,未发表),只有一项项目关注自尊(奥戴亚2000年),因此无法通过荟萃分析评估这些方法的效果。关于潜在有害影响,没有足够的证据表明本评价中纳入的任何预防项目造成了伤害。
尽管合并比较中均未显示出伤害证据,但本评价中唯一显著的合并效应并不足以就饮食失调预防项目对儿童和青少年的影响得出任何确凿结论。从临床角度来看,由于缺乏与饮食失调相关的风险因素的知识,以及在提供饮食失调预防干预措施与考虑潜在危害之间需要取得平衡,预防项目的开发和完善变得复杂。从研究角度来看,已经提出了识别有发展饮食失调风险的年轻人的“阈值”概念,而否认担忧或否认患病是与饮食失调症状学早期识别相关的另一个复杂问题。为了证明饮食失调及相关风险因素的发生率下降,需要在整个发育过程中监测干预方法的长期效果。