在针对促黄体生成素释放激素免疫的大鼠中，促黄体生成素释放激素的一种高活性类似物对促性腺激素释放的影响
Gonadotrophin release by a highly active analogue of luteinizing hormone releasing hormone in rats immunized against luteinizing hormone releasing hormone.
作者信息
Fraser H M, Sandow J
出版信息
J Endocrinol. 1977 Aug;74(2):291-6. doi: 10.1677/joe.0.0740291.
Immunization against luteinizing hormone releasing hormone (LH-RH) in adult male rats produced a progressive decline in LH and FSH in the circulation to low or non-detectable levels. D-Serine-tertiary-butyl6,des-glycine-NH210 LH-RH ethylamide is an analogue of LH-RH having highly active LH-RH properties in the normal rat. Because it is also immunologically different from LH-RH it can stimulate gonadotrophin release from the anterior pituitary gland of rats immunized against LH-RH without interference from the antibody. The analogue stimulated LH and FSH release in rats 15 weeks after immunization against LH-RH when antibody titre was highest, and after long-term (35 weeks) immunization against LH-RH. D-Serine-tertiary-butyl6,des-glycine-NH210 LH-RH ethylamide and related analogues are therefore potentially useful for reversing the effects of immunization against LH-RH.
成年雄性大鼠针对促黄体生成素释放激素（LH-RH）进行免疫后，循环中的LH和FSH水平逐渐下降至低水平或无法检测到的水平。D-丝氨酸-叔丁基6，去甘氨酸-NH210 LH-RH乙酰胺是一种LH-RH类似物，在正常大鼠中具有高度活跃的LH-RH特性。由于它在免疫学上也与LH-RH不同，因此它可以刺激针对LH-RH免疫的大鼠垂体前叶释放促性腺激素，而不受抗体的干扰。在针对LH-RH免疫15周后（此时抗体滴度最高）以及针对LH-RH进行长期（35周）免疫后，该类似物均可刺激大鼠LH和FSH的释放。因此，D-丝氨酸-叔丁基6，去甘氨酸-NH210 LH-RH乙酰胺及相关类似物可能有助于逆转针对LH-RH免疫的影响。
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