Department of Pharmacology, Father Muller Medical College Hospital, Kankanady, Mangalore, Karnataka, India.
Father Muller Medical College Hospital, Kankanady, Mangalore, Karnataka, India.
Indian J Cancer. 2020 Oct-Dec;57(4):405-410. doi: 10.4103/ijc.IJC_565_18.
In elderly people, the body's metabolic processes are not optimal and pharmacokinetics and pharmacodynamic profile of drugs are compromised or reduced. Under these conditions, the concomitant use of diverse classes of drugs can potentially increase the risk of adverse reactions and drug interactions. This will consequentially affect the already debilitated organ system. As far as the authors are aware, there are no studies addressing the drug-drug interactions and adverse drug reactions due to polypharmacy in older patients with cancer and therefore, we conducted this study.
This was an observational chart-based study and was carried out in a tertiary care cancer hospital. The data concerning prescription of all prescribed medications were noted down from the medication chart of the patient in the wards.
The most common drug-to-drug interaction that could have happened was due to the combination of theophylline with budesonide (26.10%). Adverse drug reactions were noted during the course of time, the most common being nausea and vomiting (71.9%).
As the geriatric population is increasing, the need to address medical problems among aged patients with cancer is the need of the hour. The adverse drug reactions and drug interactions that have occurred were lesser when compared to published observations.
老年人的身体代谢过程并不理想，药物的药代动力学和药效学特征也受到影响或降低。在这些情况下，同时使用多种类别的药物可能会增加不良反应和药物相互作用的风险。这将对已经受损的器官系统产生影响。据作者所知，目前尚无研究针对癌症老年患者因多种药物治疗而导致的药物-药物相互作用和不良反应，因此我们进行了这项研究。
这是一项观察性基于图表的研究，在一家三级癌症专科医院进行。从病房患者的用药图表中记录了所有规定药物的处方数据。
最有可能发生的药物-药物相互作用是茶碱与布地奈德（26.10%）的组合。在治疗过程中观察到了不良反应，最常见的是恶心和呕吐（71.9%）。
随着老年人口的增加，解决老年癌症患者的医疗问题是当务之急。与已发表的观察结果相比，发生的不良反应和药物相互作用较少。
