Department of Medical Oncology, National Institute of Oncology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
Tumori. 2021 Aug;107(4):335-340. doi: 10.1177/0300891620964571. Epub 2020 Oct 20.
Mutations in the epidermal growth factor receptor () gene are commonly observed in non-small cell lung cancer (NSCLC), particularly in adenocarcinoma histology. The frequency of mutations is ethnicity-dependent, with a higher proportion reported in Asian populations than Caucasian populations. There is a lack of data on these mutations in north Africa.
Tumor specimens from Moroccan patients with NSCLC were collected from five pathology laboratories between November 2010 and December 2017 to determine frequency and types of mutations. Tumors were tested in a reference center for by polymerase chain reaction and sequencing of exons 18, 19, 20, and 21.
A total of 334 patients were enrolled: 242 (72.5%) males and 92 females (27.5%). A total of 56.9% had a history of smoking. testing of the 334 lung adenocarcinoma samples demonstrated a wild-type in 261 (78.1%) and mutated in 73 (21.9%). Mutations were mainly detected in the exon 19 deletion (65.8%), followed by exon 21 L858 (17.8%) and other exon 21 codon mutations (5.5%) and exon 18 (6.8%), whereas primary mutations of exon 20 were less frequent (4.1%). In patients with advanced NSCLC, the detection of mutation was independently associated with sex (41.3% female vs 14.5% male; < 0.001) and smoking status (34.8% nonsmokers vs 12.9% active smokers; < 0.001). The mean age was significantly different between the two groups ( = 0.041).
Our findings confirm the genetic heterogeneity of NSCLC worldwide, reporting frequency of mutations in Moroccan patients with NSCLC between those of Asian and Caucasian populations.
表皮生长因子受体（）基因突变在非小细胞肺癌（NSCLC）中很常见，尤其是在腺癌组织学中。突变的频率与种族有关，亚洲人群的比例高于白种人群。北非缺乏关于这些突变的数据。
从 2010 年 11 月至 2017 年 12 月，从五个病理实验室收集了摩洛哥 NSCLC 患者的肿瘤标本，以确定的突变频率和类型。在参考中心通过聚合酶链反应和外显子 18、19、20 和 21 的测序测试肿瘤中的。
共纳入 334 例患者：242 例（72.5%）为男性，92 例为女性（27.5%）。56.9%有吸烟史。对 334 例肺腺癌样本进行检测，发现 261 例（78.1%）为野生型，73 例（21.9%）为突变型。突变主要发生在外显子 19 缺失（65.8%），其次是外显子 21 L858（17.8%）和其他外显子 21 密码子突变（5.5%）和外显子 18（6.8%），而外显子 20 的原发性突变较少（4.1%）。在晚期 NSCLC 患者中，检测到突变与性别（41.3%女性与 14.5%男性；<0.001）和吸烟状况（34.8%非吸烟者与 12.9%主动吸烟者；<0.001）独立相关。两组间的平均年龄差异有统计学意义（=0.041）。
我们的研究结果证实了全球 NSCLC 的遗传异质性，报告了摩洛哥 NSCLC 患者的突变频率在亚洲和白种人群之间。
