Department of Urology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Kita-gun, Miki-cho, Kagawa, 761-0793, Japan.
Department of Hygiene, Faculty of Medicine, Kagawa University Hospital, Miki, Kagawa, Japan.
World J Urol. 2021 Jul;39(7):2491-2497. doi: 10.1007/s00345-020-03494-4. Epub 2020 Oct 20.
To evaluate the health-related quality of life (HRQoL) of Japanese men on active surveillance (AS) in the Prostate cancer Research International Active Surveillance study in Japan (PRIAS-JAPAN).
Participants were included in the PRIAS-JAPAN HRQoL study between January 2010 and March 2016. Their general HRQoL was assessed using a validated Japanese version of the Short-Form 8 Health Survey (SF-8) at enrolment and annually thereafter until discontinuation of AS. The SF-8 mental component summary (MCS) and physical component summary (PCS) of men on AS were compared with scores of the general population (norm-based score [NBS]: 50) and MCS and PCS scores for men following AS were analysed over time. We tested whether MCS and PCS scores over time explained discontinuation of AS.
Five hundred and twenty-five patients enrolled, and the median age at baseline was 68 years. At enrolment and after 1-, 2-, and 3-year follow-ups, the PCS and MCS scores were significantly higher than the NBS of the general Japanese population except for the median PCS at 3 years. We found that age at diagnosis and time on AS negatively affected the PCS score of men on AS, while every additional year on AS led to a 0.27 point increase in MCS scores. Neither PCS nor MCS were predictors for discontinuation of AS.
Japanese men following an AS strategy for 3 years reported better HRQoL compared with the general population, indicating that monitoring Japanese low-risk prostate cancer patients can be an effective treatment strategy.
Clinical trial registry-UMIN (University Hospital Medical Information Network); UMIN000002874 (2009/12/11).
评估日本主动监测（AS）患者的健康相关生活质量（HRQoL），研究数据来自日本前列腺癌研究国际主动监测研究（PRIAS-JAPAN）。
参与者于 2010 年 1 月至 2016 年 3 月期间被纳入 PRIAS-JAPAN 的 HRQoL 研究。他们的一般 HRQoL 通过使用经过验证的日本版短表 8 健康调查（SF-8）进行评估，在入组时和之后每年进行一次，直至 AS 停止。将 AS 患者的 SF-8 精神健康量表（MCS）和身体健康量表（PCS）与一般人群的基准分数（NBS：50）进行比较，并分析 AS 后随时间推移的 MCS 和 PCS 分数。我们检验了随时间推移的 MCS 和 PCS 分数是否可以解释 AS 的停止。
共纳入 525 例患者，基线时的中位年龄为 68 岁。在入组时以及 1、2、3 年随访时，除了 3 年时的 MCS 中位数外，PCS 和 MCS 评分均显著高于日本一般人群的 NBS。我们发现，诊断时的年龄和 AS 的时间长短对 AS 患者的 PCS 评分有负面影响，而 AS 时间每增加一年，MCS 评分则增加 0.27 分。无论是 PCS 还是 MCS，都不是 AS 停止的预测因素。
与一般人群相比，接受 AS 策略治疗 3 年的日本男性报告了更好的 HRQoL，这表明监测日本低危前列腺癌患者可以是一种有效的治疗策略。
临床试验注册处-UMIN（大学医院医疗信息网络）；UMIN000002874（2009 年 12 月 11 日）。
