Al-Sabah Salman, Al-Haddad Mohannad, Al-Youha Sarah, Jamal Mohammad, Almazeedi Sulaiman
COVID-19 Research Group, Jaber Al-Ahmad Al-Sabah Hospital, Kuwait City, Kuwait.
College of Medicine, Kuwait University, Kuwait City, Kuwait.
Clin Obes. 2020 Dec;10(6):e12414. doi: 10.1111/cob.12414. Epub 2020 Oct 20.
The coronavirus disease 2019 (COVID-19) pandemic is straining the healthcare system, particularly for patients with severe outcomes requiring admittance to the intensive care unit (ICU). This study investigated the potential associations of obesity and diabetes with COVID-19 severe outcomes, assessed as ICU admittance. Medical history, demographic and patient characteristics of a retrospective cohort (1158 patients) hospitalized with COVID-19 were analysed at a single centre in Kuwait. Univariate and multivariate analyses were performed to explore the associations between different variables and ICU admittance. Of 1158 hospitalized patients, 271 had diabetes, 236 had hypertension and 104 required admittance into the ICU. From patients with available measurements, 157 had body mass index (BMI) ≥25 kg/m . Univariate analysis showed that overweight, obesity class I and morbid obesity were associated with ICU admittance. Patients with diabetes were more likely to be admitted to the ICU. Two models for multivariate regression analysis assessed either BMI or diabetes on ICU outcomes. In the BMI model, class I and morbid obesities were associated with ICU admittance. In the diabetes model, diabetes was associated with increased ICU admittance, whereas hypertension had a protective effect on ICU admittance. In our cohort, overweight, obesity and diabetes in patients with COVID-19 were associated with ICU admittance, increasing the risk of poor outcomes.
2019年冠状病毒病（COVID-19）大流行正在使医疗系统不堪重负，尤其是对于那些病情严重需要入住重症监护病房（ICU）的患者。本研究调查了肥胖和糖尿病与COVID-19严重后果（以入住ICU衡量）之间的潜在关联。在科威特的一个单一中心，对1158例因COVID-19住院的回顾性队列患者的病史、人口统计学和患者特征进行了分析。进行单变量和多变量分析以探讨不同变量与入住ICU之间的关联。在1158例住院患者中，271例患有糖尿病，236例患有高血压，104例需要入住ICU。在有可用测量值的患者中，157例体重指数（BMI）≥25kg/m²。单变量分析显示，超重、I类肥胖和病态肥胖与入住ICU有关。糖尿病患者更有可能入住ICU。两种多变量回归分析模型评估了BMI或糖尿病对ICU结局的影响。在BMI模型中，I类肥胖和病态肥胖与入住ICU有关。在糖尿病模型中，糖尿病与入住ICU增加有关，而高血压对入住ICU有保护作用。在我们的队列中，COVID-19患者中的超重、肥胖和糖尿病与入住ICU有关，增加了不良结局的风险。
