Shaw G K, Majumdar S K, Waller S, MacGarvie J, Dunn G
Bexley Hospital, Kent.
Br J Psychiatry. 1987 Feb;150:164-8. doi: 10.1192/bjp.150.2.164.
Thirty-two chemically dependent alcoholics with significant levels of anxiety or depression were admitted to a double-blind randomised study in which the effect of the substituted benzamide tiapride was compared with that of placebo over a 6-month period. Twenty patients completed the study. Assessments included relevant biochemical and haematological tests, drinking levels and associated behaviour, expressed satisfaction with various areas of life, the Crown-Crisp Experimental Index of neurotic symptoms and questionnaires on self-esteem and alcohol dependence. The results indicated that in comparison with the placebo group, patients treated with tiapride drank less and had longer periods of abstinence. This was associated with improvements in laboratory tests, reduction in neurotic symptoms, gains in self-esteem and increased levels of expressed satisfaction with life situation. The drug was well tolerated and no deleterious effects were noted, suggesting its potential usefulness for this patient group.
32名患有严重焦虑或抑郁的酒精依赖者被纳入一项双盲随机研究，该研究在6个月的时间里比较了取代苯甲酰胺硫必利与安慰剂的效果。20名患者完成了研究。评估包括相关的生化和血液学检查、饮酒量及相关行为、对生活各个方面的满意度、神经质症状的克朗-克里斯普实验指数以及关于自尊和酒精依赖的问卷。结果表明，与安慰剂组相比，接受硫必利治疗的患者饮酒量减少，戒酒时间更长。这与实验室检查的改善、神经质症状的减轻、自尊的提升以及对生活状况的满意度提高有关。该药物耐受性良好，未发现有害影响，表明其对该患者群体具有潜在的实用性。
