Oregon Health & Science University, Department of Neurology, United States of America.
Oregon Health & Science University, Department of Neurology, United States of America.
Int J Psychophysiol. 2020 Dec;158:103-113. doi: 10.1016/j.ijpsycho.2020.10.002. Epub 2020 Oct 17.
Evidence suggests that mindfulness meditation training has the potential to train aspects of attention. However, the neurophysiological mechanisms underpinning the attentional benefits from mindfulness remain unclear. This randomized controlled trial examined changes in electrophysiological markers of attention before and after completion of a 6-week internet-based mindfulness intervention. EEG and ERP data were collected from 64 generally healthy, mildly stressed older adults. Participants were randomized to an internet-based mindfulness-based stress reduction course (IMMI), an internet-based health and wellness education course, or a waitlist control condition. Attentional N2 and P3 evoked potentials were derived from active and passive auditory oddball paradigms. Participants in the IMMI group showed significantly greater differences in P3 peak-trough amplitude between the active and passive oddball paradigms at endpoint relative to controls. There were no significant relationships between the intervention and N2 potentials. Our data demonstrate a measurable increase in attentional control when discriminating or directing attention away from auditory stimuli for older adult participants who received mindfulness training. These findings lend support to the use of the P3 as a neurophysiological measure of meditation engagement and intervention efficacy.
证据表明，正念冥想训练有可能训练注意力的各个方面。然而，正念对注意力的益处的神经生理机制仍不清楚。这项随机对照试验在完成 6 周基于互联网的正念干预前后，检查了注意力的电生理标记物的变化。从 64 名一般健康、轻度压力的老年人中收集了 EEG 和 ERP 数据。参与者被随机分配到基于互联网的正念减压课程 (IMMI)、基于互联网的健康和养生教育课程或候补控制条件。从主动和被动听觉奇偶校验范式中得出了注意 N2 和 P3 诱发电位。与对照组相比，IMMI 组的参与者在终点时，主动和被动奇偶校验范式之间的 P3 峰-谷振幅差异显著更大。干预与 N2 电位之间没有显著关系。我们的数据表明，对于接受正念训练的老年参与者，在辨别或引导注意力远离听觉刺激时，注意力控制有可衡量的提高。这些发现为使用 P3 作为冥想参与和干预效果的神经生理测量提供了支持。
