Ross C A, Matas M
Department of Psychiatry, University of Manitoba, Winnipeg.
Can J Psychiatry. 1987 Jun;32(5):351-5. doi: 10.1177/070674378703200505.
In double-blind trials with hundreds of patients, buspirone has proven to be as effective an anxiolytic as the benzodiazepines. It causes less sedation and motor impairment than diazepam, and may be particularly useful in geriatric patients. We conducted a 4 week double-blind, randomized trial of buspirone versus diazepam and placebo in thirty adult outpatients with generalized anxiety disorder. Maximum doses were 40 mg of diazepam or buspirone or eight placebo tablets a day. There were no significant differences in outcome between the three groups on any physician or subject measures. Some implications of this finding are discussed.
在针对数百名患者的双盲试验中，已证明丁螺环酮作为一种抗焦虑药与苯二氮䓬类药物同样有效。它引起的镇静作用和运动功能损害比地西泮少，可能对老年患者特别有用。我们对30名患有广泛性焦虑症的成年门诊患者进行了一项为期4周的丁螺环酮与地西泮及安慰剂的双盲随机试验。最大剂量为每天40毫克地西泮或丁螺环酮或8片安慰剂。在任何医生或受试者测量指标上，三组之间的结果均无显著差异。本文讨论了这一发现的一些影响。
