Department of Gynecology and Obstetrics, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
Department of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
Cells. 2020 Oct 17;9(10):2312. doi: 10.3390/cells9102312.
Anti-Müllerian hormone (AMH) is responsible for the Müllerian ducts' regression in male fetuses. In cells of cancers with AMH receptors (AMHRII), AMH induces cell cycle arrest or apoptosis. As AMH occurs naturally and does not exhibit significant side effects while reducing neoplastic cell colonies, it can be considered as a potential therapeutic agent for cancer treatment. The purpose of this study was to assess the AMHRII expression in endometrial cancer (EC) in correlation to various demographic data and clinical conditions. Immunohistochemical analysis was used to assess AMHRII expression in EC tissue samples retrieved from 230 women with pre-cancerous state of endometrium (PCS) and EC. AMHRII was detected in 100% of samples. No statistical difference was observed for AMHRII expression depending on the histopathological type of EC, cancer staging, body mass index, and age, as well as the number of years of menstruation, births and miscarriages, and average and total breastfeeding time. Diabetes mellitus type 2 is the only factor that has an impact on AMHRII expression in EC tissue. Thus, this study supports the idea of theoretical use of AMH in EC treatment because all histopathological types of EC at all stages of advancement present receptors for AMH.
抗苗勒管激素 (AMH) 负责男性胎儿中缪勒管的退化。在具有 AMH 受体 (AMHRII) 的癌症细胞中，AMH 诱导细胞周期停滞或细胞凋亡。由于 AMH 是天然存在的，并且在减少肿瘤细胞集落的同时不会表现出明显的副作用，因此它可以被认为是癌症治疗的潜在治疗剂。本研究旨在评估子宫内膜癌 (EC) 中 AMHRII 的表达与各种人口统计学数据和临床状况的相关性。免疫组织化学分析用于评估从 230 名患有子宫内膜癌前状态 (PCS) 和 EC 的女性的 EC 组织样本中 AMHRII 的表达。在 100%的样本中检测到 AMHRII。AMHRII 的表达不受 EC 的组织病理学类型、癌症分期、体重指数和年龄以及月经、分娩和流产次数、平均和总母乳喂养时间的影响，也没有统计学差异。2 型糖尿病是影响 EC 组织中 AMHRII 表达的唯一因素。因此，这项研究支持在 EC 治疗中理论上使用 AMH 的想法，因为所有组织学类型的 EC 在所有进展阶段都存在 AMH 的受体。
