Gowkielewicz Marek, Lipka Aleksandra, Piotrowska Aleksandra, Szadurska-Noga Marta, Nowakowski Jacek J, Lepiarczyk Ewa, Wiszpolska Marta, Waśniewski Tomasz, Dzięgiel Piotr, Kaleczyc Jerzy, Majewski Mariusz Krzysztof, Majewska Marta
Department of Gynecology and Obstetrics, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-045 Olsztyn, Poland.
Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Chałubińskiego Street 6a, 50-368 Wroclaw, Poland.
Cancers (Basel). 2023 Feb 15;15(4):1228. doi: 10.3390/cancers15041228.
Kisspeptin (KISS) is a natural peptide-discovered in 1996 as a factor inhibiting the ability to metastasize in malignant melanoma. This protein plays also a regulatory role in the process of puberty, the menstrual cycle, spermatogenesis, implantation and development of the human placenta. The present study aimed to evaluate the expression of KISS and its receptor GPR54 in endometrial cancer (EC) tissue, depending on the histological type of cancer, its stage, various demographic characteristics, and clinical conditions in 214 hysterectomy patients. Expression of KISS and GPR54 was confirmed in 99.5% and 100% of the cases, respectively. Hormone replacement therapy and the coexistence of the anti-Müllerian type 2 receptor in cancer tissue enhanced KISS expression. Smoking, on the other hand, decreased KISS expression. GPR54 expression increased with the advancement of the disease (according to FIGO classification). Also, the presence of the anti-Müllerian type 2 receptor in EC increased the level of GPR54. Hypertension, age and miscarriage harmed the presence of GPR54. The histological type of cancer, diabetes type 2, body mass index, hormonal contraception, number of deliveries, birth weight of newborns, breastfeeding time, and the presence of AMH in EC tissue were not associated with the expression of either KISS nor GPR54. The KISS level was also significantly related to the GPR54 level. Considering that KISS is a non-toxic peptide with antimetastatic properties, further investigation is essential to determine the clinical significance of this peptide.
亲吻素（KISS）是一种天然肽，于1996年被发现，是一种抑制恶性黑色素瘤转移能力的因子。这种蛋白质在青春期、月经周期、精子发生、人类胎盘的着床和发育过程中也发挥着调节作用。本研究旨在评估214例子宫切除患者子宫内膜癌（EC）组织中KISS及其受体GPR54的表达情况，该表达情况取决于癌症的组织学类型、分期、各种人口统计学特征和临床状况。分别在99.5%和100%的病例中证实了KISS和GPR54的表达。激素替代疗法以及癌组织中抗苗勒管2型受体的共存增强了KISS的表达。另一方面，吸烟会降低KISS的表达。GPR54的表达随着疾病进展（根据国际妇产科联盟（FIGO）分类）而增加。此外，EC中抗苗勒管2型受体的存在增加了GPR54的水平。高血压、年龄和流产会损害GPR54的存在。癌症的组织学类型、2型糖尿病、体重指数、激素避孕、分娩次数、新生儿出生体重、母乳喂养时间以及EC组织中抗苗勒管激素（AMH）的存在与KISS和GPR54的表达均无关联。KISS水平也与GPR54水平显著相关。鉴于KISS是一种具有抗转移特性的无毒肽，进一步研究以确定该肽的临床意义至关重要。
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