非编码RNA与遗传性出血性毛细血管扩张症
Non-Coding RNAs and Hereditary Hemorrhagic Telangiectasia.
作者信息
Cannavicci Anthony, Zhang Qiuwang, Kutryk Michael J B
机构信息
Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.
Division of Cardiology, Keenan Research Center for Biomedical Sciences, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, ON M5B 1T8, Canada.
出版信息
J Clin Med. 2020 Oct 17;9(10):3333. doi: 10.3390/jcm9103333.
Non-coding RNAs (ncRNAs) are functional ribonucleic acid (RNA) species that include microRNAs (miRs), a class of short non-coding RNAs (∼21-25 nucleotides), and long non-coding RNAs (lncRNAs) consisting of more than 200 nucleotides. They regulate gene expression post-transcriptionally and are involved in a wide range of pathophysiological processes. Hereditary hemorrhagic telangiectasia (HHT) is a rare disorder inherited in an autosomal dominant fashion characterized by vascular dysplasia. Patients can develop life-threatening vascular malformations and experience severe hemorrhaging. Effective pharmacological therapies are limited. The study of ncRNAs in HHT is an emerging field with great promise. This review will explore the current literature on the involvement of ncRNAs in HHT as diagnostic and pathogenic factors.
非编码RNA（ncRNAs）是一类功能性核糖核酸（RNA）分子，包括微小RNA（miRs），这是一类短链非编码RNA（约21-25个核苷酸），以及由200多个核苷酸组成的长链非编码RNA（lncRNAs）。它们在转录后水平调节基因表达，并参与广泛的病理生理过程。遗传性出血性毛细血管扩张症（HHT）是一种以常染色体显性方式遗传的罕见疾病，其特征为血管发育异常。患者可能会出现危及生命的血管畸形，并经历严重出血。有效的药物治疗方法有限。对HHT中ncRNAs的研究是一个极具前景的新兴领域。本综述将探讨关于ncRNAs作为诊断和致病因素参与HHT的当前文献。
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