抗生物膜的FeO@C-[1,3,4]噻二唑并[3,2-a]嘧啶-4-鎓-2-硫醇盐衍生物核壳纳米涂层

Anti-biofilm FeO@C-[1,3,4]thiadiazolo[3,2-]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings.

作者信息

Olar Rodica, Badea Mihaela, Maxim Cătălin, Grumezescu Alexandru Mihai, Bleotu Coralia, Măruţescu Luminiţa, Chifiriuc Mariana Carmen

机构信息

Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, Romania.

Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania.

出版信息

Materials (Basel). 2020 Oct 17;13(20):4640. doi: 10.3390/ma13204640.

The derivatives 5,7-dimethyl[1,3,4]thiadiazolo[3,2-]pyrimidin-4-ium-2-thiolate () and 7-methyl-5-phenyl[1,3,4]thiadiazolo[3,2-]pyrimidin-4-ium-2-thiolate () were fully characterized by single-crystal X-ray diffraction. Their supramolecular structure is built through both π-π stacking and C=S-π interactions for both compounds. The embedment of the tested compounds into FeO@C core-shell nanocoatings increased the protection degree against biofilms on the catheter surface, suggesting that these bioactive nanocoatings could be further developed as non-cytotoxic strategies for fighting biofilm-associated fungal infections.