University of Bucharest, Faculty of Biology, Research Institute of The University of Bucharest (ICUB), Bucharest, Romania.
Future Microbiol. 2020 May;15:679-698. doi: 10.2217/fmb-2019-0251. Epub 2020 Jun 4.
Biofilms are highly tolerant to antimicrobial agents and adverse environmental conditions being important reservoirs for chronic and hard-to-treat infections. Nanomaterials exhibit microbiostatic/microbicidal/antipathogenic properties and can be also used for the delivery of antibiofilm agents. However, few of the many promising leads offered by nanotechnology reach clinical studies and eventually, become available to clinicians. The aim of this paper was to review the progress and challenges in the development of nanotechnology-based antibiofilm drug-delivery systems. The main identified challenges are: most papers report only studies of the activity of different nanoformulations; lack of standardization in the methodological approaches; insufficient collaboration between material science specialists and clinicians; paucity of studies to test efficiency and safety.
生物膜对抗菌剂和不利环境条件具有很强的耐受性，是慢性和难治性感染的重要储库。纳米材料具有抑菌/杀菌/抗病原体的特性，也可用于递送电生物膜制剂。然而，纳米技术提供的许多有希望的研究线索很少能进入临床研究，最终也无法为临床医生所用。本文的目的是综述基于纳米技术的抗生物膜药物传递系统的研究进展和挑战。主要确定的挑战是：大多数论文仅报道了不同纳米制剂活性的研究；方法学方法缺乏标准化；材料科学专家与临床医生之间合作不足；缺乏测试效率和安全性的研究。
