Woo Yu Ri, Kim Hei Sung, Lee Se Hoon, Ju Hyun Jeong, Bae Jung Min, Cho Sang Hyun, Lee Jeong Deuk
Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
J Clin Med. 2020 Oct 17;9(10):3336. doi: 10.3390/jcm9103336.
Recent evidence links rosacea to systemic disease, but there are not enough methodologic studies addressing this association in Asians. Our aim was to identify rosacea comorbidities in Koreans and establish a reference database. A multi-center, case-control study was performed where a total of 12,936 rosacea patients and 12,936 age- and sex-matched control subjects were identified from 2007 to 2018. Logistic regression was performed to find significant association between rosacea and Sjögren syndrome (odds ratio [OR] 2.05; 95% confidence interval, 1.40-3.00), systemic sclerosis (OR 6.56; 95% CI, 1.50-28.7), rheumatoid arthritis (OR 1.72; 95% CI, 1.50-1.98), ankylosing spondylitis (OR 2.32; 95% CI, 1.42-3.84), autoimmune thyroiditis (OR 1.96; 95% CI, 1.40-2.73), alopecia areata (OR 1.77; 95% CI, 1.27-2.45), vitiligo (OR 1.90; 95% CI, 1.30-2.77), lung cancer (OR 1.54; 95% CI, 1.06-2.21), hepatobiliary cancer (OR 1.38; 95% CI, 1.06-1.77), alcohol abuse (OR 1.59; 95% CI, 1.05-2.39), diabetes mellitus (OR 1.11; 95% 1.02-1.19), obesity (OR 1.72; 95% CI, 1.22-2.41), allergic rhinitis (OR 1.65; 95% CI, 1.54-1.76), allergic conjunctivitis (OR 1.57; 95% CI, 1.27-1.94), chronic rhinosinusitis (OR 1.28; 95% CI, 1.14-1.42), herpes infection (OR 1.69; 95% CI, 1.53-1.86), and human papillomavirus infection (OR 2.50; 95% CI, 2.06-3.02). Higher odds for Sjogren syndrome, systemic sclerosis, ankylosing spondylitis, thyroiditis, vitiligo, hepatobiliary cancer, and obesity was exclusive in female subjects with rosacea, whereas increased prevalence of alopecia areata and alcohol abuse was confined to men. Only those who were 50 years and older exhibited higher odds for vitiligo, lung cancer, and gastroesophageal reflux disease while individuals younger than 50 were exclusively associated with hepatobiliary cancer, allergic conjunctivitis, and irritable bowel syndrome. Our study suggests that Koreans with rosacea are more likely to experience systemic comorbidity. Clinicians should acknowledge these interrelations and employ comprehensive care with an individual-based approach.
近期证据表明酒渣鼻与全身性疾病有关，但针对亚洲人这一关联的方法学研究不足。我们的目的是确定韩国酒渣鼻患者的合并症并建立一个参考数据库。我们进行了一项多中心病例对照研究，从2007年至2018年共确定了12936名酒渣鼻患者和12936名年龄及性别匹配的对照受试者。进行逻辑回归分析以发现酒渣鼻与干燥综合征（比值比[OR]2.05；95%置信区间，1.40 - 3.00）、系统性硬化症（OR 6.56；95% CI，1.50 - 28.7）、类风湿性关节炎（OR 1.72；95% CI，1.50 - 1.98）、强直性脊柱炎（OR 2.32；95% CI，1.42 - 3.84）、自身免疫性甲状腺炎（OR 1.96；95% CI，1.40 - 2.73）、斑秃（OR 1.77；95% CI，1.27 - 2.45）、白癜风（OR 1.90；95% CI，1.30 - 2.77）、肺癌（OR 1.54；95% CI，1.06 - 2.21）、肝胆癌（OR 1.38；95% CI，1.06 - 1.77）、酒精滥用（OR 1.59；95% CI，1.05 - 2.39）、糖尿病（OR 1.11；95% 1.02 - 1.19）、肥胖症（OR 1.72；95% CI，1.22 - 2.41）、变应性鼻炎（OR 1.65；95% CI，1.54 - 1.76）、变应性结膜炎（OR 1.57；95% CI，1.27 - 1.94）、慢性鼻 - 鼻窦炎（OR 1.28；95% CI，1.14 - 1.42）、疱疹感染（OR 1.69；95% CI，1.53 - 1.86）和人乳头瘤病毒感染（OR 2.50；95% CI，2.06 - 3.02）之间的显著关联。干燥综合征、系统性硬化症、强直性脊柱炎、甲状腺炎、白癜风、肝胆癌和肥胖症的较高比值比仅在患有酒渣鼻的女性受试者中出现，而斑秃和酒精滥用患病率的增加仅限于男性。只有50岁及以上的人群患白癜风、肺癌和胃食管反流病的几率较高，而50岁以下的个体仅与肝胆癌、变应性结膜炎和肠易激综合征有关。我们的研究表明，患有酒渣鼻的韩国人更有可能出现全身性合并症。临床医生应认识到这些相互关系，并采用基于个体的综合护理方法。
