School of Medicine, Tzu-Chi University, Hualien 97004, Taiwan.
Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97010, Taiwan.
Int J Environ Res Public Health. 2020 Oct 18;17(20):7567. doi: 10.3390/ijerph17207567.
Adipocyte fatty acid binding protein (A-FABP) is predictive of type 2 diabetes mellitus incidences and metabolic syndrome and is independently associated with atherosclerosis. The present study aimed to assess the association between serum A-FABP levels and future first hospitalization events in kidney transplantation (KT). We enrolled 72 KT patients from January through April 2012 and followed up on these subjects until June 2017. The first hospitalization events incidence was the primary endpoint. Using a commercially available enzyme immunoassay, serum A-FABP levels were measured from the patient's fasting blood samples. During a median 65-month follow-up, 49 first hospitalization events occurred. KT patients with first hospitalization events had greater incidences of hypertension, diabetes, and higher serum blood urea nitrogen, creatinine, triglyceride, and A-FABP levels than those without the events. Kaplan-Meier analysis showed that the cumulative incidence of first hospitalization events was greater in the high A-FABP group than in the low A-FABP group. Multivariate Cox analysis with significant variables showed that serum A-FABP (hazard ratio = 1.012; 95% confidence interval = 1.000-1.025; = 0.044) was independently associated with first hospitalization events among KT patients. The results revealed that serum A-FABP is associated with first hospitalization events in KT patients. However, further prospective studies are needed to determine the mechanisms underlying this association.
脂肪细胞脂肪酸结合蛋白（A-FABP）可预测 2 型糖尿病的发生率和代谢综合征，并且与动脉粥样硬化独立相关。本研究旨在评估血清 A-FABP 水平与肾移植（KT）患者未来首次住院事件之间的关系。我们于 2012 年 1 月至 4 月期间招募了 72 名 KT 患者，并对这些患者进行了随访，直至 2017 年 6 月。首次住院事件的发生率是主要终点。使用商业上可获得的酶联免疫吸附试验，从患者的空腹血样中测量血清 A-FABP 水平。在中位数为 65 个月的随访期间，发生了 49 次首次住院事件。发生首次住院事件的 KT 患者比未发生该事件的患者高血压、糖尿病的发生率更高，血清血尿素氮、肌酐、甘油三酯和 A-FABP 水平也更高。Kaplan-Meier 分析显示，高 A-FABP 组的首次住院事件累积发生率大于低 A-FABP 组。具有显著变量的多变量 Cox 分析表明，血清 A-FABP（风险比=1.012；95%置信区间=1.000-1.025；P=0.044）与 KT 患者的首次住院事件独立相关。结果表明，血清 A-FABP 与 KT 患者的首次住院事件相关。然而，需要进一步的前瞻性研究来确定这种关联的机制。
