Graduate Interdisciplinary Program in Applied Mathematics, University of Arizona, Tucson, AZ, USA.
Environmental Resilience Institute, Indiana University, Bloomington, IN, USA.
Proc Biol Sci. 2020 Oct 28;287(1937):20201503. doi: 10.1098/rspb.2020.1503. Epub 2020 Oct 21.
The extended evolutionary synthesis invokes a role for development in shaping adaptive evolution, which in population genetics terms corresponds to mutation-biased adaptation. Critics have claimed that clonal interference makes mutation-biased adaptation rare. We consider the behaviour of two simultaneously adapting traits, one with larger mutation rate , the other with larger selection coefficient , using asexual travelling wave models. We find that adaptation is dominated by whichever trait has the faster rate of adaptation in isolation, with the other trait subject to evolutionary stalling. Reviewing empirical claims for mutation-biased adaptation, we find that not all occur in the 'origin-fixation' regime of population genetics where is only twice as sensitive to as to . In some cases, differences in are at least ten to twelve times larger than differences in , as needed to cause mutation-biased adaptation even in the 'multiple mutations' regime. Surprisingly, when > in the 'diffusive-mutation' regime, the required sensitivity ratio is also only two, despite pervasive clonal interference. Given two traits with identical , the benefit of having higher is surprisingly small, occurring largely when one trait is at the boundary between the origin-fixation and multiple mutations regimes.
扩展进化综合论提出了发育在塑造适应性进化中的作用,这在群体遗传学中对应于偏向突变的适应。批评者声称克隆干扰使偏向突变的适应变得罕见。我们考虑了两个同时适应的特征的行为,一个具有较大的突变率 ,另一个具有较大的选择系数 ,使用无性传播波模型。我们发现,适应主要由在孤立状态下适应速度更快的特征主导,另一个特征则受到进化停滞的影响。在审查偏向突变的适应的经验主张时,我们发现并非所有情况都发生在群体遗传学的“起源固定”(origin-fixation) 状态,其中 对 的敏感性仅为 对 的两倍。在某些情况下, 之间的差异至少是 的十倍到十二倍,这足以在“多次突变”(multiple mutations) 状态下引起偏向突变的适应。令人惊讶的是,当 在“扩散突变”(diffusive-mutation) 状态下大于 时,所需的敏感性比也是仅为 2,尽管存在普遍的克隆干扰。当 时,对于两个具有相同 的特征,具有更高 的优势非常小,主要发生在一个特征处于起源固定和多次突变之间的边界时。