Suppr超能文献

突变偏向会影响经历克隆干扰的大型无性繁殖群体的适应性。

Mutation bias can shape adaptation in large asexual populations experiencing clonal interference.

机构信息

Graduate Interdisciplinary Program in Applied Mathematics, University of Arizona, Tucson, AZ, USA.

Environmental Resilience Institute, Indiana University, Bloomington, IN, USA.

出版信息

Proc Biol Sci. 2020 Oct 28;287(1937):20201503. doi: 10.1098/rspb.2020.1503. Epub 2020 Oct 21.

Abstract

The extended evolutionary synthesis invokes a role for development in shaping adaptive evolution, which in population genetics terms corresponds to mutation-biased adaptation. Critics have claimed that clonal interference makes mutation-biased adaptation rare. We consider the behaviour of two simultaneously adapting traits, one with larger mutation rate , the other with larger selection coefficient , using asexual travelling wave models. We find that adaptation is dominated by whichever trait has the faster rate of adaptation in isolation, with the other trait subject to evolutionary stalling. Reviewing empirical claims for mutation-biased adaptation, we find that not all occur in the 'origin-fixation' regime of population genetics where is only twice as sensitive to as to . In some cases, differences in are at least ten to twelve times larger than differences in , as needed to cause mutation-biased adaptation even in the 'multiple mutations' regime. Surprisingly, when > in the 'diffusive-mutation' regime, the required sensitivity ratio is also only two, despite pervasive clonal interference. Given two traits with identical , the benefit of having higher is surprisingly small, occurring largely when one trait is at the boundary between the origin-fixation and multiple mutations regimes.

摘要

扩展进化综合论提出了发育在塑造适应性进化中的作用,这在群体遗传学中对应于偏向突变的适应。批评者声称克隆干扰使偏向突变的适应变得罕见。我们考虑了两个同时适应的特征的行为,一个具有较大的突变率 ,另一个具有较大的选择系数 ,使用无性传播波模型。我们发现,适应主要由在孤立状态下适应速度更快的特征主导,另一个特征则受到进化停滞的影响。在审查偏向突变的适应的经验主张时,我们发现并非所有情况都发生在群体遗传学的“起源固定”(origin-fixation) 状态,其中 对 的敏感性仅为 对 的两倍。在某些情况下, 之间的差异至少是 的十倍到十二倍,这足以在“多次突变”(multiple mutations) 状态下引起偏向突变的适应。令人惊讶的是,当 在“扩散突变”(diffusive-mutation) 状态下大于 时,所需的敏感性比也是仅为 2,尽管存在普遍的克隆干扰。当 时,对于两个具有相同 的特征,具有更高 的优势非常小,主要发生在一个特征处于起源固定和多次突变之间的边界时。

相似文献

1
Mutation bias can shape adaptation in large asexual populations experiencing clonal interference.
Proc Biol Sci. 2020 Oct 28;287(1937):20201503. doi: 10.1098/rspb.2020.1503. Epub 2020 Oct 21.
2
Evolution of Mutation Rates in Rapidly Adapting Asexual Populations.
Genetics. 2016 Nov;204(3):1249-1266. doi: 10.1534/genetics.116.193565. Epub 2016 Sep 19.
3
The influence of deleterious mutations on adaptation in asexual populations.
PLoS One. 2011;6(11):e27757. doi: 10.1371/journal.pone.0027757. Epub 2011 Nov 14.
4
Rate of adaptation in sexuals and asexuals: a solvable model of the Fisher-Muller effect.
Genetics. 2013 Nov;195(3):941-55. doi: 10.1534/genetics.113.155135. Epub 2013 Aug 26.
5
Interfering waves of adaptation promote spatial mixing.
Genetics. 2011 Nov;189(3):1045-60. doi: 10.1534/genetics.111.130112. Epub 2011 Sep 6.
6
Limits to adaptation in asexual populations.
J Evol Biol. 2005 Jul;18(4):779-88. doi: 10.1111/j.1420-9101.2005.00879.x.
7
Sex speeds adaptation by altering the dynamics of molecular evolution.
Nature. 2016 Mar 10;531(7593):233-6. doi: 10.1038/nature17143. Epub 2016 Feb 24.
8
Clonal interference, multiple mutations and adaptation in large asexual populations.
Genetics. 2008 Dec;180(4):2163-73. doi: 10.1534/genetics.108.090019. Epub 2008 Oct 1.
9
Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations.
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4950-5. doi: 10.1073/pnas.1119910109. Epub 2012 Feb 27.
10
The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation.
Theor Popul Biol. 2008 Feb;73(1):24-46. doi: 10.1016/j.tpb.2007.10.004. Epub 2007 Oct 22.

引用本文的文献

1
2
Non-hypermutator cancers access driver mutations through reversals in germline mutational bias.
bioRxiv. 2024 Nov 26:2024.04.30.591900. doi: 10.1101/2024.04.30.591900.
4
Shifts in Mutation Bias Promote Mutators by Altering the Distribution of Fitness Effects.
Am Nat. 2023 Oct;202(4):503-518. doi: 10.1086/726010. Epub 2023 Aug 23.
5
Shifts in mutation spectra enhance access to beneficial mutations.
Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2207355120. doi: 10.1073/pnas.2207355120. Epub 2023 May 22.
6
Distribution of mutation rates challenges evolutionary predictability.
Microbiology (Reading). 2023 May;169(5). doi: 10.1099/mic.0.001323.
7
Mutation bias and the predictability of evolution.
Philos Trans R Soc Lond B Biol Sci. 2023 May 22;378(1877):20220055. doi: 10.1098/rstb.2022.0055. Epub 2023 Apr 3.
8
Exploring the expanse between theoretical questions and experimental approaches in the modern study of evolvability.
J Exp Zool B Mol Dev Evol. 2023 Jan;340(1):8-17. doi: 10.1002/jez.b.23134. Epub 2022 Apr 22.
9
Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution.
Nat Ecol Evol. 2022 Apr;6(4):439-447. doi: 10.1038/s41559-022-01669-3. Epub 2022 Mar 3.
10
Mutation bias shapes the spectrum of adaptive substitutions.
Proc Natl Acad Sci U S A. 2022 Feb 15;119(7). doi: 10.1073/pnas.2119720119.

本文引用的文献

1
Evolutionary stalling and a limit on the power of natural selection to improve a cellular module.
Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18582-18590. doi: 10.1073/pnas.1921881117. Epub 2020 Jul 17.
3
Parallel Evolution of HIV-1 in a Long-Term Experiment.
Mol Biol Evol. 2019 Nov 1;36(11):2400-2414. doi: 10.1093/molbev/msz155.
4
A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism.
Cell Rep. 2019 Jun 11;27(11):3359-3370.e7. doi: 10.1016/j.celrep.2019.05.030.
5
The role of mutation bias in adaptive molecular evolution: insights from convergent changes in protein function.
Philos Trans R Soc Lond B Biol Sci. 2019 Jul 22;374(1777):20180238. doi: 10.1098/rstb.2018.0238. Epub 2019 Jun 3.
6
Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis.
PLoS Biol. 2019 May 13;17(5):e3000265. doi: 10.1371/journal.pbio.3000265. eCollection 2019 May.
7
The Role of Mutation Bias in Adaptive Evolution.
Trends Ecol Evol. 2019 May;34(5):422-434. doi: 10.1016/j.tree.2019.01.015.
8
Directional Selection Rather Than Functional Constraints Can Shape the G Matrix in Rapidly Adapting Asexuals.
Genetics. 2019 Feb;211(2):715-729. doi: 10.1534/genetics.118.301685. Epub 2018 Dec 17.
9
Gene Birth Contributes to Structural Disorder Encoded by Overlapping Genes.
Genetics. 2018 Sep;210(1):303-313. doi: 10.1534/genetics.118.301249. Epub 2018 Jul 19.
10
Rapid adaptation in large populations with very rare sex: Scalings and spontaneous oscillations.
Theor Popul Biol. 2019 Oct;129:18-40. doi: 10.1016/j.tpb.2017.11.005. Epub 2017 Dec 12.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验