Department of Urology, Foundation IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Int J Impot Res. 2022 Jan;34(1):71-80. doi: 10.1038/s41443-020-00366-8. Epub 2020 Oct 20.
Currently available surgical treatments for Lower Urinary Tract Symptoms (LUTS) due to Benign Prostatic Obstruction (BPO) are associated with an increased risk of sexual dysfunction. The aim of our study is to compare sexual and ejaculatory function after Holmium Laser Enucleation of the Prostate (HoLEP) and Bipolar Transurethral Enucleation of the Prostate (B-TUEP). We performed a retrospective analysis of data prospectively collected from 62 (44.9%) and 76 (55.1%) patients who underwent HoLEP and B-TUEP, respectively. Erectile function and ejaculation characteristics were assessed with the International Index of Erectile Function-Erectile Function (IIEF-EF) domain and the Male Sexual Health Questionnaire-Ejaculatory function (MSHQ-EJ) questionnaires. Our study recorded no change in erectile function and no significant difference in rates of preserved antegrade ejaculation after both surgeries. One month after surgery, rates of physical pain/discomfort and perceived decreased physical pleasure during ejaculation were higher in HoLEP than B-TUEP patients (all p < 0.03). Moreover, HoLEP patients were more bothered by their ejaculatory difficulties than B-TUEP men (p = 0.03). At 3- and 12-months follow-up, all ejaculation-related differences disappeared. In conclusion, both procedures are valid alternatives for BPO treatment as they offer comparable urinary and sexual outcomes in the long term. However, in the first month after surgery, HoLEP patients present with more ejaculatory difficulties.
目前,针对良性前列腺增生(BPO)导致的下尿路症状(LUTS)的手术治疗与性功能障碍风险增加相关。我们的研究旨在比较经尿道钬激光前列腺剜除术(HoLEP)和经尿道双极前列腺剜除术(B-TUEP)后对性功能和射精功能的影响。我们对分别接受 HoLEP 和 B-TUEP 治疗的 62 例(44.9%)和 76 例(55.1%)患者前瞻性收集的数据进行了回顾性分析。采用国际勃起功能指数问卷-勃起功能(IIEF-EF)域和男性性健康问卷-射精功能(MSHQ-EJ)问卷评估勃起功能和射精特征。我们的研究记录到两种手术均未改变勃起功能,并且两种手术的顺行性射精保留率没有显著差异。手术后 1 个月,HoLEP 组患者在射精过程中身体疼痛/不适和感知身体愉悦度下降的发生率高于 B-TUEP 组(均 p<0.03)。此外,HoLEP 组患者对射精困难的困扰程度大于 B-TUEP 组(p=0.03)。在 3 个月和 12 个月的随访中,所有与射精相关的差异均消失。总之,这两种手术都是治疗 BPO 的有效替代方法,因为它们在长期随访中提供相似的尿控和性功能结果。然而,在手术后 1 个月,HoLEP 组患者出现更多的射精困难。