Shih J C, Sandholm M, Scott M L
J Nutr. 1977 Sep;107(9):1583-9. doi: 10.1093/jn/107.9.1583.
A selenium deficiency in chicks produces degeneration and fibrosis of the pancreas. An investigation was undertaken to determine whether or not the activity of lipoic acid is impaired in the pancreas of selenium-deficient chicks. Enzymatic analyses of selenium-deficient chick tissues showed a reduction in lipoamide dehydrogenase both in pancreas and liver at a very early stage of growth. Using both direct measurements and sucrose-gradient cellular fractionation, it was found that the lipoamide dehydrogenase activity of the supernatant increased, and that of the mitochondria decreased in selenium-deficient as compared to normal chick livers. These results indicate an increased fragility of the mitochondrial membranes in selenium-deficient chicks.
雏鸡缺硒会导致胰腺退化和纤维化。开展了一项调查，以确定缺硒雏鸡胰腺中硫辛酸的活性是否受损。对缺硒雏鸡组织进行的酶分析表明，在生长的早期阶段，胰腺和肝脏中的硫辛酰胺脱氢酶均减少。通过直接测量和蔗糖梯度细胞分级分离发现，与正常雏鸡肝脏相比，缺硒雏鸡肝脏上清液中的硫辛酰胺脱氢酶活性增加，而线粒体中的活性降低。这些结果表明缺硒雏鸡线粒体膜的脆性增加。
