Department of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland.
Dis Markers. 2020 Oct 1;2020:8847211. doi: 10.1155/2020/8847211. eCollection 2020.
. The main goal of the study was to assess the usefulness of plasma concentrations of catestatin as a predictor of a composite endpoint (CE): unplanned hospitalization and death for all causes in patients with HFrEF in the midterm follow-up. . The study group consisted of 52 Caucasian patients in NYHA classes II and III. The control group consisted of 24 healthy volunteers. The biomarkers, whose concentration was assessed before and after physical exertion as well as the variability of their concentration under the influence of the physical exertion, were NT-proBNP, troponin T, and catestatin. . During the 24-month follow-up period, 11 endpoints were recorded. The univariate analysis of the Cox proportional hazard model showed a statistically significant effect of all assessed CST concentrations on the occurrence of CE. In the 24-month follow-up, where the starting concentration of catestatin was compared with other recognized prognostic factors in HF, the initial concentration of catestatin showed statistical significance in CE prognosis as the only parameter tested. . Plasma concentration of catestatin before and after physical exertion is a valuable prognostic parameter in predicting death from all causes and unplanned hospitalization in the group of patients with HFrEF in the 2-year follow-up.
. 本研究的主要目的是评估血浆茶抑素浓度作为复合终点（CE）的预测因子的有用性：在中期随访中，HFpEF 患者的非计划性住院和全因死亡。. 研究组包括 52 名 NYHA Ⅱ和Ⅲ级的白种人患者。对照组包括 24 名健康志愿者。评估了生物标志物的浓度，这些生物标志物的浓度在体力活动前后以及在体力活动的影响下其浓度的可变性进行了评估，这些生物标志物是 NT-proBNP、肌钙蛋白 T 和茶抑素。. 在 24 个月的随访期间，记录了 11 个终点。Cox 比例风险模型的单变量分析显示，所有评估 CST 浓度对 CE 发生的影响均具有统计学意义。在 24 个月的随访中，将茶抑素的起始浓度与 HF 中其他公认的预后因素进行比较，在 CE 预后中，茶抑素的起始浓度显示出统计学意义，是唯一经过测试的参数。. 运动前后的血浆茶抑素浓度是预测 HFpEF 患者 2 年随访中全因死亡和非计划性住院的有价值的预后参数。
