Halabi Rami, Abdessater Maher, Boustany Johnny, Kanbar Anthony, Akl Halim, El Khoury Joey, El Hachem Charbel, El Khoury Raghid
Department of Urology, Notre Dame des Secours University Hospital Center (CHUNDS), Byblos City, Lebanon.
Faculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK), Jounieh, Lebanon.
Case Rep Urol. 2020 Oct 5;2020:8827646. doi: 10.1155/2020/8827646. eCollection 2020.
Large cell neuroendocrine carcinoma (LCNC) is one of the rarest types of bladder cancer occurring in <1%. Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. The patient was a 64-year-old smoker male, who presented for the first time with dysuria and hematuria. A bladder tumor invading the anterior and right lateral bladder walls was discovered, without any secondary localizations. Tumor biopsy showed an LCNC with adenocarcinomatous components. The patient was treated by recurrent tumor resections, chemotherapy, and radiotherapy. No improvement was noted despite close follow-up and adequate treatment. Neuroendocrine bladder tumor is known to have an aggressive, rapid, and disadvantageous evolution. Multiple case reports were published so far, and a recent review was conducted in March 2020 by Sanguedolce et al. (2020). More cases are needed to establish the best management plan for this type of tumor.
大细胞神经内分泌癌（LCNC）是最罕见的膀胱癌类型之一，发病率低于1%。无论为单纯型还是与其他成分混合型，它始终是最具侵袭性的膀胱癌类型之一。我们报告一例伴有腺癌成分的膀胱LCNC病例。患者为一名64岁男性吸烟者，首次因排尿困难和血尿就诊。发现一个侵犯膀胱前壁和右侧壁的膀胱肿瘤，无任何继发性定位。肿瘤活检显示为伴有腺癌成分的LCNC。患者接受了复发性肿瘤切除术、化疗和放疗。尽管进行了密切随访和充分治疗，但未见改善。已知神经内分泌膀胱肿瘤具有侵袭性、快速且不利的病程。迄今为止已发表了多篇病例报告，Sanguedolce等人于2020年3月进行了一项最新综述。需要更多病例来制定针对此类肿瘤的最佳管理方案。
