Dowd Katherine, Rotenberry Charles, Russell Douglas, Wachtel Mitchell, de Riese Werner
Department of Urology, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA.
Department of Pathology, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA.
Case Rep Med. 2017;2017:4812453. doi: 10.1155/2017/4812453. Epub 2017 Jan 2.
Neuroendocrine tumors rarely occur in the urinary bladder. They can be carcinomatous, subdivided into small cell and large cell pathology. Small cell carcinoma of the bladder is a rarity that may present at an advanced pathologic stage. No treatment regimens have been standardized for local or metastatic disease. Review of the recent literature shows equivalent survival data for localized disease treated with chemoradiotherapy combined with either bladder sparing surgery or radical cystectomy. Patients with significant comorbidities are an additional challenge. We report a case of poorly differentiated neuroendocrine tumor of the bladder, which could not be classified as small or large cell carcinoma, complicated by significant comorbidities. After management with transurethral resection of the tumor, adjuvant chemotherapy, and radiation, the patient is alive and asymptomatic nearly 1 year after initial TURBT with no evidence of disease recurrence.
神经内分泌肿瘤很少发生于膀胱。它们可以是癌性的，细分为小细胞和大细胞病理类型。膀胱小细胞癌很罕见，可能在病理晚期出现。对于局部或转移性疾病，尚无标准化的治疗方案。近期文献回顾显示，接受放化疗联合膀胱保留手术或根治性膀胱切除术治疗的局限性疾病患者，其生存数据相当。伴有严重合并症的患者是另一项挑战。我们报告一例膀胱低分化神经内分泌肿瘤病例，该肿瘤无法归类为小细胞或大细胞癌，且伴有严重合并症。在经尿道肿瘤切除、辅助化疗和放疗后，患者在首次经尿道膀胱肿瘤电切术后近1年仍存活且无症状，无疾病复发迹象。
