Lopedote Paolo, Yosef Amir, Kozyreva Olga
Department of Medicine, St Elizabeth's Medical Center, Boston, Massachusetts, USA.
Department of Medical Oncology, St Elizabeth's Medical Center, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Case Rep Oncol. 2022 Mar 29;15(1):326-337. doi: 10.1159/000521607. eCollection 2022 Jan-Apr.
Neuroendocrine (NE) tumors of the bladder are infrequent. Among them, large cell NE tumor has been outlined only in case reports and short case series, which describes them as aggressive malignancies with dismal prognosis requiring a multidisciplinary approach. The case of an 82-year-old patient with muscle-invasive large cell NE carcinoma of the bladder associated with urothelial carcinoma in situ is presented. Despite combined treatment modality, relapse with metastatic disease was detected 12.5 months after the initial diagnosis. Thereafter, we review several published cases, and results of the collected data are compared with the largest studies published on this topic.
膀胱神经内分泌（NE）肿瘤较为罕见。其中，大细胞NE肿瘤仅在病例报告和简短病例系列中有所描述，这些报告将其描述为侵袭性恶性肿瘤，预后不佳，需要多学科治疗方法。本文介绍了一例82岁患有肌肉浸润性膀胱大细胞NE癌并伴有原位尿路上皮癌的患者。尽管采用了联合治疗方式，但在初次诊断后12.5个月仍检测到伴有转移性疾病的复发。此后，我们回顾了几例已发表的病例，并将收集到的数据结果与关于该主题发表的最大规模研究进行了比较。
