Ha Ngoc-Tram, Lowery Megan, Woo Jean, Mehta Yatin, Bhanot Nitin
Division of Pulmonary and Critical Care Medicine, Geisinger Medical Center, Danville, PA, 17882, United States.
Division of Infectious Disease, Allegheny General Hospital, Allegheny Health Network, PA 15212, United States.
IDCases. 2020 Oct 1;22:e00979. doi: 10.1016/j.idcr.2020.e00979. eCollection 2020.
Isolated cerebral mucormycosis is a relatively rare and unique variant of mucormycosis which is seen most commonly in patients with intravenous recreational drug use. While this invasive fungal infection in the brain is thought to spread from the sinuses or the lungs in other hosts such as diabetics and those with malignancy, hematogenous spread and seeding has been attributed in the pathogenesis of isolated cerebral mucormycosis. Clinical features and radiological findings may be non-specific and hence, heightened clinical suspicion for a prompt diagnosis and early medical and surgical intervention is paramount for a favorable outcome in such rare, but potentially fatal infections.
孤立性脑毛霉菌病是毛霉菌病中一种相对罕见且独特的类型,最常见于静脉注射毒品的患者。虽然在糖尿病患者和恶性肿瘤患者等其他宿主中,这种脑部侵袭性真菌感染被认为是从鼻窦或肺部传播而来,但血行播散和播散性种植被认为是孤立性脑毛霉菌病发病机制的原因。临床特征和影像学表现可能不具有特异性,因此,对于这种罕见但可能致命的感染,提高临床怀疑以进行快速诊断以及早期药物和手术干预对于获得良好预后至关重要。