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表现为卒中及脑脓肿的孤立性脑毛霉菌病:一例报告并文献复习

Isolated cerebral mucormycosis that looks like stroke and brain abscess: A case report and review of the literature.

作者信息

Chen Cai-Hong, Chen Jing-Nan, Du Hang-Gen, Guo Dong-Liang

机构信息

Department of Neurology, Hangzhou Ninth People's Hospital, Hangzhou 311225, Zhejiang Province, China.

Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310005, Zhejiang Province, China.

出版信息

World J Clin Cases. 2023 Mar 6;11(7):1560-1568. doi: 10.12998/wjcc.v11.i7.1560.

Abstract

BACKGROUND

Cerebral mucormycosis is an infectious disease of the brain caused by fungi of the order Mucorales. These infections are rarely encountered in clinical practice and are often misdiagnosed as cerebral infarction or brain abscess. Increased mortality due to cerebral mucormycosis is closely related to delayed diagnosis and treatment, both of which present unique challenges for clinicians.

CASE SUMMARY

Cerebral mucormycosis is generally secondary to sinus disease or other disseminated disease. However, in this retrospective study, we report and analyze a case of isolated cerebral mucormycosis.

CONCLUSION

The constellation of symptoms including headaches, fever, hemiplegia, and changes in mental status taken together with clinical findings of cerebral infarction and brain abscess should raise the possibility of a brain fungal infection. Early diagnosis and prompt initiation of antifungal therapy along with surgery can improve patient survival.

摘要

背景

脑毛霉菌病是一种由毛霉目真菌引起的脑部感染性疾病。这些感染在临床实践中很少见,常被误诊为脑梗死或脑脓肿。脑毛霉菌病导致的死亡率增加与诊断和治疗延迟密切相关,这两者都给临床医生带来了独特的挑战。

病例摘要

脑毛霉菌病通常继发于鼻窦疾病或其他播散性疾病。然而,在这项回顾性研究中,我们报告并分析了一例孤立性脑毛霉菌病病例。

结论

包括头痛、发热、偏瘫和精神状态改变在内的一系列症状,以及脑梗死和脑脓肿的临床发现,应提高脑部真菌感染的可能性。早期诊断、及时开始抗真菌治疗以及手术可以提高患者的生存率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba5/10011993/44d5567eee88/WJCC-11-1560-g001.jpg

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