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樟脑对四氧嘧啶诱导的糖尿病大鼠肝脏、肾脏和胰腺组织抗氧化防御系统的调节作用

Modulation of the antioxidant defense system in liver, kidney, and pancreas tissues of alloxan-induced diabetic rats by camphor.

作者信息

Drikvandi Parivash, Bahramikia Seifollah, Alirezaei Masoud

机构信息

Department of Biology, Faculty of Science, Lorestan University, Khorramabad, Iran.

Division of Biochemistry, School of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

出版信息

J Food Biochem. 2020 Dec;44(12):e13527. doi: 10.1111/jfbc.13527. Epub 2020 Oct 20.

Abstract

Excess production of reactive oxygen species and the loss of antioxidant efficiency systems play an important role in the development of diabetes. Thus, using antioxidant compounds is an important strategy to reduce these complications. This study aimed to investigate the possible effect of camphor on the serum biochemical parameters and oxidative parameters in the pancreas, liver, and kidney tissues of alloxan-induced diabetic rats. In this study, 40 male Wistar rats were divided into five groups, including normal group, diabetic group, the diabetic group treated with glibenclamide, the diabetic group treated with 30 mg/kg camphor, and the diabetic group receiving the camphor solvent. Intragastric administration of camphor and glibenclamide, as the control drug, to diabetic rats for 21 days lowered their blood glucose, total cholesterol, triglyceride, and LDL-cholesterol, while the blood high-density lipoprotein -cholesterol level was increased. In addition, our results indicated that treatment of diabetic rats with camphor increased the activity of glutathione peroxidase, catalase, and superoxide dismutase enzymes as well as reduced glutathione content in the liver, pancreas, and kidney tissues as compared to the diabetic rats. Based on our data, it can be concluded that camphor has a hypoglycemic activity, and this effect may be attributed, in part, to its antioxidant ability. PRACTICAL APPLICATIONS: Camphor is a terpenoid natural compound derived from the wood present in the camphor laurel's stem and roots (Cinnamomum camphora L.) trees. The synthetic form of camphor is currently being produced for medical, health, and industrial applications. In addition, this compound is present in Rosmarinus officinalis, Cinnamomum zeylanicum, Salvia officinalis, Artemisia Annua, and Ocimum basilicum. Numerous researches have shown its beneficial effects on various diseases. In this study, it has been shown that camphor possesses antidiabetic effects in alloxan-induced diabetic rats. Treatment of diabetic rats with camphor increased the antioxidant capacity and reduces the oxidative stress markers in the liver, pancreas, and kidney tissues as compared to the diabetic rats. Given the favorable effect of camphor on some oxidative parameters in diabetic rats in our study, its antihyperglycemic property is probably due to its antioxidant effects.

摘要

活性氧的过量产生以及抗氧化效率系统的丧失在糖尿病的发展中起着重要作用。因此,使用抗氧化化合物是减少这些并发症的重要策略。本研究旨在探讨樟脑对四氧嘧啶诱导的糖尿病大鼠血清生化参数以及胰腺、肝脏和肾脏组织氧化参数的可能影响。在本研究中,40只雄性Wistar大鼠被分为五组,包括正常组、糖尿病组、用格列本脲治疗的糖尿病组、用30mg/kg樟脑治疗的糖尿病组以及接受樟脑溶剂的糖尿病组。对糖尿病大鼠进行为期21天的樟脑和作为对照药物的格列本脲灌胃给药,可降低其血糖、总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平,同时提高血液高密度脂蛋白胆固醇水平。此外,我们的结果表明,与糖尿病大鼠相比,用樟脑治疗糖尿病大鼠可提高肝脏、胰腺和肾脏组织中谷胱甘肽过氧化物酶、过氧化氢酶和超氧化物歧化酶的活性以及还原型谷胱甘肽含量。根据我们的数据,可以得出结论,樟脑具有降血糖活性,且这种作用可能部分归因于其抗氧化能力。实际应用:樟脑是一种萜类天然化合物,源自樟树(樟科樟属)树干和根部的木材。樟脑的合成形式目前用于医药、健康和工业应用。此外,该化合物还存在于迷迭香、锡兰肉桂、鼠尾草、青蒿和罗勒中。众多研究表明其对多种疾病具有有益作用。在本研究中,已表明樟脑对四氧嘧啶诱导的糖尿病大鼠具有抗糖尿病作用。与糖尿病大鼠相比,用樟脑治疗糖尿病大鼠可提高肝脏、胰腺和肾脏组织的抗氧化能力并降低氧化应激标志物。鉴于本研究中樟脑对糖尿病大鼠某些氧化参数的有利影响,其降血糖特性可能归因于其抗氧化作用。

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