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原发性腹部的小肠梗阻非手术治疗:系统综述。

Non-operative management for small bowel obstruction in a virgin abdomen: a systematic review.

机构信息

Department of General Surgery, Colorectal Surgery Unit, Alfred Hospital, Melbourne, Victoria, Australia.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

出版信息

ANZ J Surg. 2021 May;91(5):802-809. doi: 10.1111/ans.16392. Epub 2020 Oct 20.

DOI:10.1111/ans.16392
PMID:33084181
Abstract

BACKGROUND

Small bowel obstruction (SBO) is a common general surgical presentation and there has been a shift towards non-operative management (NOM) for patients with previous abdominal surgery. Historically, exploratory surgery has been mandated for SBO in patients with a virgin abdomen. However, there is increasing evidence for NOM in this group of patients.

METHODS

A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A search was undertaken between 1995 and 2020 on Ovid MEDLINE, EMBASE and PubMed. Primary outcome measures were success and failure rates, whereas secondary outcome measures were morbidity, mortality rates and identifying underlying aetiologies.

RESULTS

Six observational studies were included, with 205 patients in the NOM and 211 patients in the operative group. There was a high success rate of 95.6% and low morbidity rate of 3.1% in the NOM group compared to 88.6% and 26% in the operative group, respectively. Both groups reported no mortalities. The most common aetiologies for SBO in a virgin abdomen were adhesions (63%), malignancy (11%), foreign body/bezoar (5%), internal hernia (4%) and volvulus (4%).

CONCLUSION

NOM for SBO is a safe and feasible option for a select group of clinically stable patients with a virgin abdomen without features of closed-loop obstruction. Adhesions are the most common cause of SBO in this group of patients. Further large-scale prospective clinical studies with standardized NOM modality, homogenous clinical resolution indicators and long-term follow-up data are warranted to allow for quantitative analysis to reinforce this evidence.

摘要

背景

小肠梗阻(SBO)是一种常见的普通外科疾病,对于既往有腹部手术史的患者,其治疗方式已逐渐转为非手术治疗(NOM)。既往,对于无腹部手术史的 SBO 患者,剖腹探查术是金标准。然而,目前越来越多的证据支持对这组患者采用 NOM。

方法

按照系统评价和荟萃分析的首选报告项目进行系统评价。在 1995 年至 2020 年间,在 Ovid MEDLINE、EMBASE 和 PubMed 上进行了检索。主要结局指标为成功率和失败率,次要结局指标为发病率、死亡率和明确潜在病因。

结果

共纳入 6 项观察性研究,NOM 组 205 例,手术组 211 例。NOM 组的成功率为 95.6%,发病率为 3.1%,而手术组的成功率为 88.6%,发病率为 26%。两组均无死亡病例。无腹部手术史患者 SBO 的最常见病因是粘连(63%)、恶性肿瘤(11%)、异物/胃石(5%)、内疝(4%)和扭转(4%)。

结论

对于无腹部手术史且无闭袢性梗阻特征的临床稳定患者,NOM 是一种安全可行的选择。粘连是该组患者 SBO 的最常见病因。需要进一步开展大型前瞻性临床研究,采用标准化的 NOM 方式、同质的临床缓解指标和长期随访数据,以便进行定量分析,从而进一步证实这一证据。

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