血清长链非编码 RNA TINCR 可作为预测三阴性乳腺癌患者预后的新型生物标志物。
Serum lncRNA TINCR Serve as a Novel Biomarker for Predicting the Prognosis in Triple-Negative Breast Cancer.
机构信息
Department of Radiotherapy, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Xiaojie Wang and Shuang Li contributed equally to this work.
出版信息
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820965574. doi: 10.1177/1533033820965574.
BACKGROUND
Tissue differentiation-inducing non-protein coding RNA (TINCR) has been shown to play a crucial role in pathogenesis of various types of human cancer including breast cancer (BC). The purpose of this study was to determine the potential prognostic value of serum lncRNA TINCR in BC.
METHODS
Quantitative reverse transcription PCR (qRT-PCR) was performed to detect serum lncRNA TINCR levels in 72 triple-negative BC (TNBC) patients, 105 non-TNBC patients, 60 benign breast disease patients and 86 healthy subjects.
RESULTS
The results showed that serum lncRNA TINCR level was significantly increased in BC, especially in TNBC. High circulating lncRNA TINCR was significantly correlated with worse clinicopathological features and clinical outcome of TNBC. Multivariate analysis revealed that serum lncRNA TINCR was an independent prognostic factor for overall survival of TNBC. However, little association was found between serum lncRNA TINCR and the prognosis of non-TNBC.
CONCLUSIONS
Taken together, our findings demonstrate that serum lncRNA TINCR might be a useful novel and non-invasive biomarker for the prognosis prediction of TNBC.
背景
组织分化诱导非蛋白编码 RNA（TINCR）已被证明在包括乳腺癌（BC）在内的多种类型人类癌症的发病机制中发挥着关键作用。本研究旨在确定血清 lncRNA TINCR 在 BC 中的潜在预后价值。
方法
采用定量逆转录 PCR（qRT-PCR）检测 72 例三阴性 BC（TNBC）患者、105 例非 TNBC 患者、60 例良性乳腺疾病患者和 86 例健康对照者的血清 lncRNA TINCR 水平。
结果
结果显示，BC 患者，尤其是 TNBC 患者血清 lncRNA TINCR 水平显著升高。高循环 lncRNA TINCR 与 TNBC 的不良临床病理特征和临床结局显著相关。多因素分析显示，血清 lncRNA TINCR 是 TNBC 患者总生存期的独立预后因素。然而，血清 lncRNA TINCR 与非 TNBC 的预后之间几乎没有关联。
结论
综上所述，我们的研究结果表明，血清 lncRNA TINCR 可能是 TNBC 预后预测的一种有用的新型非侵入性生物标志物。
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