Rodrigues Andrea Bezerra, Aguiar Maria Isis Freire De, Oliveira Patrícia Peres De, Alves Naiana Pacifico, Silva Renan Alves, Vitorino Willame De Oliveira, Lopes Thays Silva De Souza
Universidade Federal do Ceará, Departamento de Enfermagem, Fortaleza, CE, Brazil.
Universidade Federal de São João Del Rey, Departamento de Enfermagem, Divinópolis, MG, Brazil.
Rev Lat Am Enfermagem. 2020 Oct 19;28:e3363. doi: 10.1590/1518-8345.3953.3363. eCollection 2020.
to evaluate the effect of oral cryotherapy compared to physiological serum on the development of oral mucositis in outpatient cancer patients using the 5-fluorouracil antineoplastic agent.
this is a controlled, randomized, double-blind, and multi-center clinical trial, conducted with 60 patients undergoing chemotherapy. The experimental group (n=30) used oral cryotherapy during the infusion of the 5-FU antineoplastic agent, while the control group (n=30) performed mouthwash with physiological serum at their homes. The oral cavity of the participants was assessed at three times: before randomization, and on the 7th and 14th days after using 5-FU. For data analysis, descriptive analyses and the ANOVA, paired t, and McNemar tests were used.
there was no statistically significant difference between the experimental and control groups in the assessments regarding the grade of mucositis. However, cryotherapy presented the chance to reduce the presence of intragroup mucositis, between the first and second assessments (p=0.000126).
cryotherapy did not obtain statistical significance in relation to oral hygiene with serum, but it proved to be effective intragroup. Record number: RBR-4k7zh3.
评估与生理血清相比，口服冷冻疗法对使用5-氟尿嘧啶抗肿瘤药物的门诊癌症患者口腔黏膜炎发展的影响。
这是一项对照、随机、双盲、多中心临床试验，对60名接受化疗的患者进行。实验组（n = 30）在输注5-FU抗肿瘤药物期间采用口服冷冻疗法，而对照组（n = 30）在家中用生理血清进行漱口。在三个时间点对参与者的口腔进行评估：随机分组前，以及使用5-FU后的第7天和第14天。数据分析采用描述性分析以及方差分析、配对t检验和McNemar检验。
在黏膜炎分级评估方面，实验组和对照组之间没有统计学上的显著差异。然而，冷冻疗法显示出在第一次和第二次评估之间降低组内黏膜炎发生率的可能性（p = 0.000126）。
冷冻疗法与血清口腔卫生相比未获得统计学意义，但在组内证明是有效的。记录编号：RBR-4k7zh3。
