Okamoto Koichi, Ninomiya Itasu, Yamaguchi Takahisa, Terai Shiro, Nakanuma Shinichi, Kinoshita Jun, Makino Isamu, Nakamura Keishi, Miyashita Tomoharu, Tajima Hidehiro, Takamura Hiroyuki, Fushida Sachio, Ohta Tetsuo
Department of Gastroenterological Surgery, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
Esophagus. 2019 Apr;16(2):207-213. doi: 10.1007/s10388-018-00655-8. Epub 2019 Jan 1.
Chemotherapy, including preoperative chemotherapy, plays an important role in the treatment of esophageal cancer. However, although docetaxel, cisplatin, and fluorouracil (DCF) therapy has a powerful antitumor effect, the associated adverse events make it difficult to maintain the patient's general condition. Oral mucositis is an important adverse effect of chemotherapy, and its severity, frequency, and impact on patient quality of life should not be underestimated. This study evaluated the role of oral cryotherapy for prophylaxis of oral mucositis caused by DCF therapy.
We retrospectively examined the incidence and severity of adverse events, including mucositis, in 72 patients with esophageal cancer treated with DCF. Fifty-eight patients received cryotherapy during docetaxel administration and 14 received no cryotherapy.
The incidence of mucositis of all grades and grade 3 was significantly lower in the cryotherapy group compared with the no-cryotherapy group (24.1% vs. 71.4%, P < 0.001 and 0% vs. 28.6%, P = 0.001, respectively). The incidence of anorexia of all grades and grade 3 was also significantly lower in the cryotherapy group (22.4% vs. 57.1%, P = 0.037 and 0% vs. 28.6%, P = 0.010, respectively).
Adjunctive oral cryotherapy is effective for the prophylaxis and relief of oral mucositis and anorexia caused by chemotherapy.
化疗，包括术前化疗，在食管癌治疗中发挥着重要作用。然而，尽管多西他赛、顺铂和氟尿嘧啶（DCF）疗法具有强大的抗肿瘤作用，但相关的不良事件使得维持患者的一般状况变得困难。口腔黏膜炎是化疗的一种重要不良反应，其严重程度、发生频率以及对患者生活质量的影响不容小觑。本研究评估了口腔冷冻疗法对预防DCF疗法所致口腔黏膜炎的作用。
我们回顾性研究了72例接受DCF治疗的食管癌患者不良事件（包括黏膜炎）的发生率和严重程度。58例患者在多西他赛给药期间接受了冷冻疗法，14例未接受冷冻疗法。
与未接受冷冻疗法的组相比，冷冻疗法组所有级别和3级黏膜炎的发生率均显著更低（分别为24.1% 对71.4%，P < 0.001；0% 对28.6%，P = 0.001）。冷冻疗法组所有级别和3级厌食症的发生率也显著更低（分别为22.4% 对57.1%，P = 0.037；0% 对28.6%，P = 0.0一一0）。
辅助口腔冷冻疗法对预防和缓解化疗所致口腔黏膜炎和厌食症有效。
