Cong Boyi, Zhang Qian, Cao Xuetao
Laboratory of Immunity and Inflammation, College of Life Sciences, Nankai University, Tianjin, 300071, China.
National Key Laboratory of Medical Immunology, Institute of Immunology, Navy Military Medical University, Shanghai, 200433, China.
Protein Cell. 2021 Mar;12(3):165-173. doi: 10.1007/s13238-020-00796-6. Epub 2020 Oct 21.
TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate- and Fe-dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has been widely recognized to be an important regulator for normal hematopoiesis especially myelopoiesis. Mutation and dysregulation of TET2 contribute to the development of multiple hematological malignancies. Recent studies reveal that TET2 also plays an important role in innate immune homeostasis by promoting DNA demethylation or independent of its enzymatic activity. Here, we focus on the functions of TET2 in the initiation and resolution of inflammation through epigenetic regulation and signaling network. In addition, we highlight regulation of TET2 at various molecular levels as well as the correlated inflammatory diseases, which will provide the insight to intervene in the pathological process caused by TET2 dysregulation.
TET2是10-11易位（TET）家族的成员之一，作为一种α-酮戊二酸和铁依赖性双加氧酶，催化5-甲基胞嘧啶（5mC）的迭代氧化，已被广泛认为是正常造血尤其是髓系造血的重要调节因子。TET2的突变和失调促成了多种血液系统恶性肿瘤的发生。最近的研究表明，TET2还通过促进DNA去甲基化或独立于其酶活性在先天免疫稳态中发挥重要作用。在此，我们聚焦于TET2通过表观遗传调控和信号网络在炎症起始和消退中的功能。此外，我们强调了TET2在各个分子水平的调控以及相关的炎症性疾病，这将为干预由TET2失调引起的病理过程提供思路。
