Zhao Fei, Cong Xiao, Huang Xiaobo, Zheng Yi, Zhao Qin, Wen Yiping, Wu Rui, Du Senyan, Cao Sanjie, Cong Feng, Wang Yiping
Department of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Guangdong Laboratory Animals Monitoring Institute, Guangzhou, 510663, Guangdong, China.
Vet Res. 2025 Jan 9;56(1):5. doi: 10.1186/s13567-024-01436-1.
Swine acute diarrhoea syndrome coronavirus (SADS-CoV), a novel HKU2-related coronavirus of bat origin, is a newly emerged swine enteropathogenic coronavirus that causes severe diarrhoea in piglets. SADS-CoV has a broad cell tropism with the capability to infect a wide variety of cells from human and diverse animals, which implicates its ability to hold high risks of cross-species transmission. The intracellular antiviral immunity, comprised of the intrinsic and innate immunity, represents the first line of host defence against viral infection prior to the onset of adaptive immunity. To date, there are no vaccines and drugs approved to prevent or treat SADS-CoV infection. Understanding of the mutual relationship between SADS-CoV infection and host immunity is crucial for the development of novel vaccines and drugs against SADS-CoV. Here, we review recent advancements in our understanding of the interplay between SADS-CoV infection and the host intrinsic and innate immunity. The extensive and in-depth investigation on their interactive relationship will contribute to the identification of new targets for developing intervention strategies to control SADS-CoV infection.
猪急性腹泻综合征冠状病毒（SADS-CoV）是一种源自蝙蝠的新型HKU2相关冠状病毒，是一种新出现的猪肠道致病性冠状病毒，可导致仔猪严重腹泻。SADS-CoV具有广泛的细胞嗜性，能够感染来自人类和多种动物的多种细胞，这意味着它具有很高的跨物种传播风险。由固有免疫和天然免疫组成的细胞内抗病毒免疫是宿主在适应性免疫开始之前抵御病毒感染的第一道防线。迄今为止，尚无批准用于预防或治疗SADS-CoV感染的疫苗和药物。了解SADS-CoV感染与宿主免疫之间的相互关系对于开发针对SADS-CoV的新型疫苗和药物至关重要。在此，我们综述了目前对SADS-CoV感染与宿主固有免疫和天然免疫之间相互作用的最新认识进展。对它们相互作用关系的广泛而深入的研究将有助于确定开发控制SADS-CoV感染干预策略的新靶点。
