Mei Hong-Xiang, Chen Yi-Lin, Shi Pei-Lei, Yang Si-Rui, Xu Xin, He Jin-Zhi
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Oct 1;38(5):583-588. doi: 10.7518/hxkq.2020.05.019.
Epigenetics refers to a steady change in the level of gene expression caused by non-DNA sequence changes. Microbes can modulate host inflammation through epigenetic pathways to evade or expend immune responses. As an important part of human microbes, oral bacteria also have various epigenetic regulation mechanisms to affect host inflammatory responses. This article reviews the common pathways of epigenetic regulation in microbe infection and the regulation of host epigenetics by using oral microbes to provide a reference for the study of epigenetic-related mechanisms in oral diseases.
表观遗传学是指由非DNA序列变化引起的基因表达水平的稳定变化。微生物可通过表观遗传途径调节宿主炎症，以逃避或消耗免疫反应。作为人类微生物的重要组成部分，口腔细菌也具有多种表观遗传调控机制来影响宿主炎症反应。本文综述了微生物感染中表观遗传调控的常见途径以及利用口腔微生物对宿主表观遗传学的调控，为口腔疾病中表观遗传相关机制的研究提供参考。
