Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Int J Cardiol. 2021 Feb 15;325:103-108. doi: 10.1016/j.ijcard.2020.10.031. Epub 2020 Oct 18.
Chronic heart failure (CHF) is a serious complication and a major cause of mortality in patients with Takayasu arteritis (TA). We aimed to explore the clinical features and long-term outcomes in TA patients with CHF.
Adult TA patients admitted to our hospital between January 2009 to April 2018 were classified as HF and non-HF group. The adverse events were defined as a composite of all-cause mortality and hospitalization for HF. The outcome of the HF-group was further analyzed. A total of 61 HF patients and 102 non-HF patients were identified. In the HF group, the median age at assessment was 41.9 years, and female was predominant (82.0%). The multivariable logistic regression model revealed that pulmonary hypertension, aortic regurgitation, mitral regurgitation, level albumin, and uric acid were independently associated with CHF. After a median follow-up of 1347 days, 25 adverse events occurred in HF patients, and the 5-year event-free rate was 54.7%. The Cox model showed that coronary artery involvement, aortic regurgitation, without interventional treatment were related to adverse events.
The 5-year event-free rate was not satisfying. Aggressive intervention may decreased the likelihood of adverse events in patients with CHF.
慢性心力衰竭（CHF）是 Takayasu 动脉炎（TA）患者的严重并发症和主要死亡原因。我们旨在探讨合并 CHF 的 TA 患者的临床特征和长期预后。
2009 年 1 月至 2018 年 4 月期间，我院收治的成年 TA 患者分为 HF 组和非 HF 组。不良事件定义为全因死亡率和 HF 住院的复合事件。进一步分析 HF 组的结局。共纳入 61 例 HF 患者和 102 例非 HF 患者。HF 组评估时的中位年龄为 41.9 岁，女性为主（82.0%）。多变量逻辑回归模型显示肺动脉高压、主动脉瓣反流、二尖瓣反流、白蛋白水平和尿酸与 CHF 独立相关。中位随访 1347 天后，HF 患者发生 25 例不良事件，5 年无事件生存率为 54.7%。Cox 模型显示冠状动脉受累、主动脉瓣反流、无介入治疗与不良事件相关。
5 年无事件生存率不理想。积极的介入治疗可能降低 CHF 患者不良事件的发生概率。
