多发性骨髓瘤合并前列腺癌患者化疗后前列腺特异性膜抗原摄取的变化。

The Change of 68Ga-Prostate-Specific Membrane Antigen Uptake in Myeloma After Chemotherapy in a Patient With Multiple Myeloma and Concurrent Prostate Cancer.

机构信息

From the Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital; and Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China.

出版信息

Clin Nucl Med. 2020 Dec;45(12):1013-1015. doi: 10.1097/RLU.0000000000003339.

DOI:10.1097/RLU.0000000000003339

PMID:33086276

Abstract

A bone lesion in the right calcaneus was found in a 76-year-old man with a history of prostate cancer. Ga-PSMA-11 PET/CT showed multiple PSMA-expressing lytic bone lesions in appendicular skeleton. Biopsy of the lesion in the right calcaneus confirmed plasmacytoma. After several cycles of chemotherapy, the patient was in serologically stringent complete remission. The follow-up PET/CT showed a significant reduction of Ga-PSMA-11 uptake in the previously PSMA-avid bone lesions without morphological changes on CT. The reduction of PSMA expression in myelomas after chemotherapy is suggested to result from the treatment response.

摘要

一位 76 岁的前列腺癌病史男性患者，发现右侧跟骨有一处骨病变。Ga-PSMA-11 PET/CT 显示四肢骨骼有多处 PSMA 表达的溶骨性骨病变。右侧跟骨病变活检证实为浆细胞瘤。经过几轮化疗后，患者达到血清学严格完全缓解。随访 PET/CT 显示，之前 PSMA 摄取增高的骨病变 Ga-PSMA-11 摄取显著减少，而 CT 无形态学改变。化疗后骨髓瘤 PSMA 表达减少提示治疗反应。