From the Department of Nuclear Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Clin Nucl Med. 2019 Oct;44(10):e593-e594. doi: 10.1097/RLU.0000000000002609.
Fibrous dysplasia is an uncommon benign bone pathology with only rare potential for malignant transformation. We describe the heterogeneous uptake of fibrous dysplasia of a whole rib on Ga-labeled prostate-specific membrane antigen (PSMA) PET/CT. Ga-PSMA binds to PSMA-expressing prostate cancer cells, but it can also bind to the neovasculature of various solid tumors, as well as to some benign lesions. Ga-PSMA expression in fibrous dysplasia should not automatically be equated with malignant transformation or confused with prostate cancer metastases.
纤维结构不良是一种不常见的良性骨病变，仅有极少数恶变潜能。我们描述了整根肋骨的 Ga 标记前列腺特异性膜抗原（PSMA） PET/CT 摄取不均匀。Ga-PSMA 与表达 PSMA 的前列腺癌细胞结合，但也可以与各种实体肿瘤的新生血管以及一些良性病变结合。Ga-PSMA 在纤维结构不良中的表达不应自动等同于恶性转化或与前列腺癌转移混淆。
