Inyang A L, Okpako D T, Essien E M
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.
Haematologia (Budap). 1987;20(2):101-8.
Swiss albino mice were infected by the intraperitoneal route with P. berghei berghei malaria parasite, and platelets, white cell counts and some coagulation parameters were monitored in order to find out whether changes reported in man also occurred in the mice. Parasitaemia developed form the 2nd post-infection day and reached significant levels by the 4th-6th day. Reduced circulating platelets which reached severe thrombocytopenic levels were observed. parallel with the increasing degree of parasitaemia. Anaemia which progressed to severe degree was also observed as was a slight leucocytosis attributed to the presence of normal mouse erythrocytes in the peritoneal space. All untreated animals died by the 6th day of infection. Intramuscular chloroquine sulphate (20 micrograms/g body wt.) given for 7 days completely cured the malaria, and white cell and platelet counts were restored to preinfection levels in each animal about 2 weeks after treatment had ceased. Platelet hypersensitivity to exogenous ADP was observed within 48 hours of infection and persisted with the parasitaemia. Prothrombin time (PT) and activated partial thromboplastin time (APTT) were prolonged while clottable fibrinogen concentration was reduced.
将瑞士白化小鼠通过腹腔途径感染伯氏疟原虫伯氏疟原虫，监测血小板、白细胞计数和一些凝血参数，以确定人类中报告的变化是否也在小鼠中出现。感染后第2天出现疟原虫血症，到第4 - 6天达到显著水平。观察到循环血小板减少，达到严重血小板减少水平，与疟原虫血症程度增加平行。还观察到进展为严重程度的贫血以及由于腹膜腔中存在正常小鼠红细胞而导致的轻微白细胞增多。所有未治疗的动物在感染后第6天死亡。肌肉注射硫酸氯喹（20微克/克体重）7天可完全治愈疟疾，在治疗停止后约2周，每只动物的白细胞和血小板计数恢复到感染前水平。在感染后48小时内观察到血小板对外源性ADP过敏，并随疟原虫血症持续存在。凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）延长，而可凝纤维蛋白原浓度降低。
