Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.
Viruses. 2020 Oct 19;12(10):1182. doi: 10.3390/v12101182.
Human adenoviruses (HAdVs) are common pathogens causing a variety of respiratory, ocular and gastrointestinal diseases. To accomplish their efficient replication, HAdVs take an advantage of viral small non-coding RNAs (sncRNAs), which have multiple roles during the virus lifecycle. Three of the best-characterized HAdV sncRNAs; VA RNA, mivaRNA and MLP-TSS-sRNA will be discussed in the present review. Even though VA RNA has been extensively characterized during the last 60 years, this multifunctional molecule continues to surprise us as more of its structural secrets unfold. Likely, the recent developments on mivaRNA and MLP-TSS-sRNA synthesis and function highlight the importance of these sncRNA in virus replication. Collectively, we will summarize the old and new knowledge about these three viral sncRNAs with focus on their synthesis, structure and functions.
人腺病毒（HAdVs）是常见的病原体，可引起多种呼吸道、眼部和胃肠道疾病。为了实现高效复制，HAdVs 利用病毒小非编码 RNA（sncRNA），这些 RNA 在病毒生命周期中具有多种功能。本文将讨论三种研究最为透彻的 HAdV sncRNA：VA RNA、mivaRNA 和 MLP-TSS-sRNA。尽管 VA RNA 在过去的 60 年中得到了广泛的研究，但随着更多的结构秘密被揭示，这个多功能分子仍然让我们感到惊讶。可能是由于 mivaRNA 和 MLP-TSS-sRNA 合成和功能的最新研究进展突出了这些 sncRNA 在病毒复制中的重要性。总之，我们将总结这三种病毒 sncRNA 的旧知识和新知识，重点介绍它们的合成、结构和功能。
