绵羊淋巴细胞的个体发生。II. 绵羊胎儿脾脏中T淋巴细胞发育的免疫组织学研究。

Ontogeny of ovine lymphocytes. II. An immunohistological study on the development of T lymphocytes in the sheep fetal spleen.

作者信息

Maddox J F, Mackay C R, Brandon M R

机构信息

Department of Veterinary Preclinical Sciences, University of Melbourne, Parkville, Victoria, Australia.

出版信息

Immunology. 1987 Sep;62(1):107-12.

PMID:3308689

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453735/

Abstract

The development of T and B lymphocytes in the ovine fetal spleen was studied immunohistologically using a panel of monoclonal antibodies. A specific sequence of appearance of lymphocyte markers on cells was observed. At 43-44 days of gestation, SBU-T1- and SBU-T8-positive lymphocytes were present in low numbers. However, no SBU-T4, 20.96-, 25.69-, 38.38-, or 46.66-positive lymphocytes were seen until 50-55 days of gestation. Surface immunoglobulin (sIg) was first detected on fetal spleen cells at 45-50 days of gestation. SBU-T19 lymphocytes appeared later in gestation, being observed in fetal spleens at 57 days gestational age (g.a.). The distribution of T cells, B cells and MHC antigens in the developing spleen of the ovine fetus is described.

摘要

使用一组单克隆抗体，通过免疫组织学方法研究了绵羊胎儿脾脏中T淋巴细胞和B淋巴细胞的发育情况。观察到细胞上淋巴细胞标志物出现的特定顺序。在妊娠43 - 44天时，SBU - T1和SBU - T8阳性淋巴细胞数量较少。然而，直到妊娠50 - 55天时，才观察到SBU - T4、20.96、25.69、38.38或46.66阳性淋巴细胞。表面免疫球蛋白（sIg）最早在妊娠45 - 50天时在胎儿脾细胞上被检测到。SBU - T19淋巴细胞在妊娠后期出现，在妊娠57天（胎龄，g.a.）时在胎儿脾脏中被观察到。描述了绵羊胎儿发育中的脾脏中T细胞、B细胞和MHC抗原的分布情况。