Department of Rheumatology, Tokyo Medical University Hospital, Tokyo, Japan.
Mod Rheumatol Case Rep. 2020 Jan;4(1):39-46. doi: 10.1080/24725625.2019.1651955. Epub 2019 Aug 20.
Neuropsychiatric (NP) manifestations of systemic lupus erythematosus (SLE) are diverse, but involvement of basal ganglia is rare. We describe here a 28-year-old woman with NPSLE presenting aseptic meningitis accompanied by elevated interleukin-6 levels in the cerebrospinal fluid, who developed symmetrical basal ganglia lesions, containing a cytotoxic oedematous core, surrounded by vasogenic oedema upon magnetic resonance imaging. We were able to observe these lesions from a appearance during the disease onset to its disappearance during immunosuppressive treatment. Reversibility upon immunosuppressive treatment indicated that autoimmune mediated mechanisms could contribute to the basal ganglia lesions in NPSLE.
神经精神性（NP）系统性红斑狼疮（SLE）的表现多种多样，但基底节受累很少见。我们在此描述了一例 28 岁的女性患者，患有 NPSLE，表现为无菌性脑膜炎，伴有脑脊液中白细胞介素-6 水平升高，磁共振成像显示对称性基底节病变，病变核心为细胞毒性水肿，周围为血管源性水肿。我们能够观察到这些病变从疾病发病时的 表现到免疫抑制治疗期间的消失。免疫抑制治疗后的可逆性表明，自身免疫介导的机制可能导致 NPSLE 的基底节病变。
