Watanabe Ryu, Fujii Hiroshi, Shirai Tsuyoshi, Saito Shinichiro, Hatakeyama Akira, Sugimura Koichiro, Fukumoto Yoshihiro, Ishii Tomonori, Harigae Hideo
Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Japan.
Intern Med. 2014;53(6):627-31. doi: 10.2169/internalmedicine.53.0514.
A 59-year-old woman who had been diagnosed with systemic lupus erythematosus (SLE) was admitted to our hospital due to paralysis in all of her limbs. The patient presented with dysarthria, cerebellar ataxia and hypoxia. Magnetic resonance imaging (MRI) revealed vasogenic edema in the brain stem and the cerebellum. She was diagnosed with neuropsychiatric lupus syndrome (NPSLE) and pulmonary arterial hypertension (PAH), and was successfully treated using immunosuppressive therapy. To our knowledge, this is the first reported case of simultaneously developing NPSLE and PAH.
一名59岁的女性，此前已被诊断为系统性红斑狼疮（SLE），因四肢瘫痪入住我院。患者出现构音障碍、小脑共济失调和低氧血症。磁共振成像（MRI）显示脑干和小脑存在血管源性水肿。她被诊断为神经精神性狼疮综合征（NPSLE）和肺动脉高压（PAH），并通过免疫抑制治疗成功治愈。据我们所知，这是首例同时发生NPSLE和PAH的报告病例。
