The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Mod Rheumatol Case Rep. 2020 Jul;4(2):229-232. doi: 10.1080/24725625.2020.1738988. Epub 2020 Mar 12.
Protein-losing enteropathy (PLE) is a rare organ disorder that can develop as a complication of systemic lupus erythematosus (SLE). Here, we report the case of a 59-year-old woman with SLE who experienced recurrent PLE resulting from different pathological conditions. The patient was diagnosed with SLE in X-14. In X-12, she was hospitalised due to persistent diarrhoea, generalised oedema, abdominal distension, dyspnoea on exertion, and hypoalbuminemia. A thrombus was noted in the superior mesenteric vein extending from the main trunk of the portal vein. She was diagnosed with PLE resulting from portal vein thrombosis caused by SLE, and her condition improved with anticoagulant therapy. In X-1, she developed diarrhoea and hypoalbuminemia again and was diagnosed with PLE associated with SLE. The symptoms promptly ameliorated with immunosuppressive therapy. Because PLE associated with SLE can be caused by various pathological conditions, appropriate therapeutic intervention based on the underlying condition is crucial.
蛋白丢失性肠病（PLE）是一种罕见的器官疾病，可作为系统性红斑狼疮（SLE）的并发症发展而来。在这里，我们报告了一例 59 岁女性 SLE 患者，她因不同的病理状况而反复发生 PLE。患者于 X-14 年被诊断为 SLE。在 X-12 年，她因持续性腹泻、全身性水肿、腹胀、活动后呼吸困难和低白蛋白血症住院。肠系膜上静脉主干内有血栓形成，延伸至门静脉主干。她被诊断为 SLE 引起的门静脉血栓形成导致的 PLE，抗凝治疗后病情改善。在 X-1 年，她再次出现腹泻和低白蛋白血症，被诊断为 SLE 相关的 PLE。免疫抑制治疗后症状迅速缓解。由于 SLE 相关的 PLE 可由多种病理状况引起，因此根据基础疾病进行适当的治疗干预至关重要。
