Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6200 MD Maastricht, the Netherlands.
Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University as Part of an Internship from the Health Sciences Research Master of the Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, the Netherlands.
Br J Nutr. 2021 May 28;125(10):1188-1200. doi: 10.1017/S0007114520003487. Epub 2020 Oct 22.
The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Adhering to these recommendations may have beneficial effects on patient-reported outcomes after a cancer diagnosis, but evidence is scarce. We aimed to assess associations of the individual dietary WCRF/AICR recommendations regarding fruit and vegetables, fibre, fast foods, red and processed meat, sugar-sweetened drinks and alcohol consumption with patient-reported outcomes in colorectal cancer (CRC) survivors. Cross-sectional data of 150 stage I-III CRC survivors, 2-10 years post-diagnosis, were used. Dietary intake was measured by 7-d dietary records. Validated questionnaires were used to measure health-related quality of life (HRQoL), fatigue and neuropathy. Confounder-adjusted linear regression models were used to analyse associations of each WCRF/AICR dietary recommendation with patient-reported outcomes. Higher vegetable intake (per 50 g) was associated with better global QoL (β 2·6; 95 % CI 0·6, 4·7), better physical functioning (3·3; 1·2, 5·5) and lower levels of fatigue (-4·5; -7·6, -1·4). Higher fruit and vegetables intake (per 100 g) was associated with better physical functioning (3·2; 0·8, 5·5) and higher intake of energy-dense food (per 100 kJ/100 g) with worse physical functioning (-4·2; -7·1, -1·2). No associations of dietary recommendations with neuropathy were found. These findings suggest that adhering to specific dietary WCRF/AICR recommendations is associated with better HRQoL and less fatigue in CRC survivors. Although the recommendations regarding healthy dietary habits may be beneficial for the well-being of CRC survivors, longitudinal research is warranted to gain insight into the direction of associations.
世界癌症研究基金会和美国癌症研究所（WCRF/AICR）建议癌症幸存者遵循预防癌症的生活方式建议。坚持这些建议可能对癌症诊断后的患者报告结局产生有益影响，但证据有限。我们旨在评估 WCRF/AICR 关于水果和蔬菜、纤维、快餐、红肉和加工肉、糖饮料和酒精摄入的个别饮食建议与结直肠癌（CRC）幸存者患者报告结局之间的关联。使用了 150 名 I-III 期 CRC 幸存者的横断面数据，这些幸存者在诊断后 2-10 年。通过 7 天饮食记录测量饮食摄入量。使用经过验证的问卷测量健康相关生活质量（HRQoL）、疲劳和神经病变。使用调整混杂因素的线性回归模型分析每个 WCRF/AICR 饮食建议与患者报告结局之间的关联。较高的蔬菜摄入量（每 50 克）与更好的整体 QoL（β 2·6；95 % CI 0·6, 4·7）、更好的身体机能（3·3；1·2, 5·5）和更低的疲劳水平（-4·5；-7·6, -1·4）相关。较高的水果和蔬菜摄入量（每 100 克）与更好的身体机能（3·2；0·8, 5·5）相关，而较高的能量密集型食物摄入量（每 100 kJ/100 g）与更差的身体机能相关（-4·2；-7·1, -1·2）。饮食建议与神经病变之间没有关联。这些发现表明，遵守特定的 WCRF/AICR 饮食建议与 CRC 幸存者的 HRQoL 更高和疲劳感更低有关。尽管关于健康饮食习惯的建议可能对 CRC 幸存者的幸福感有益，但需要进行纵向研究以深入了解关联的方向。
