遵守 2018 年世界癌症研究基金会和美国癌症研究所饮食建议与肠道微生物群和炎症水平的关联。
Associations of Adherence to the 2018 World Cancer Research Fund and the American Institute for Cancer Research Dietary Recommendations with Gut Microbiota and Inflammation Levels.
机构信息
Department of Epidemiology and Health Statistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
出版信息
Nutrients. 2023 Aug 24;15(17):3705. doi: 10.3390/nu15173705.
BACKGROUND
Whether the World Cancer Research Fund and the American Institute for Cancer Research (WCRF/AICR) dietary recommendations affect the gut microbiota and inflammatory status remains unclear. We examined the association of dietary adherence scores to the WCRF/AICR with gut microbiota and inflammation in a cross-sectional setting.
METHODS
The WCRF/AICR diet adherence scores were calculated for 151 participants (adenoma 97, non-adenoma 54) from 7-day dietary records. The gut microbiota was analyzed by 16S rRNA gene sequencing of fecal samples. The levels of inflammatory biomarkers in both blood (i.e., IL-6, IL-8, IgA, IgM, and IgG) and fecal samples (i.e., FCP) were evaluated in 97 colorectal adenoma patients who had blood samples available. Multivariable linear regression analyses were conducted to examine the association of individual and total dietary adherence scores with gut microbiota and inflammatory biomarker levels.
RESULTS
Participants with higher adherence had lower relative abundance of ( = -0.041, 95%: -0.073, -0.009), ( = -0.035, 95%: -0.067, -0.003), and unidentified at the genus level ( = -0.029, 95%: -0.055, -0.003) compared to those with lower adherence. Plant-based food intake was positively correlated with increased abundance of ( = 0.013, 95%: 0.001, 0.026). Restricting fast food was linked to high abundance of ( = 0.149, 95%: 0.040, 0.257) and ( = 0.149, 95%: 0.040, 0.257). Limiting sugary drinks was associated with reduced abundance of ( = -0.155, 95%: -0.292, -0.018). Plant-based food intake ( = -0.251, 95%: -0.450, -0.052) and restriction of fast food ( = -0.226, 95%: -0.443, -0.008) were associated with reduced IGG levels in men. Alcohol restriction was linked to lower IL-6 ( = -7.095, 95%: -11.286, -2.903) and IL-8 ( = -7.965, 95%: -14.700, -1.230) levels in women, but with higher IL-6 ( = 0.918, 95%: 0.161, 1.675) levels in men.
CONCLUSIONS
Our findings support the association of adherence to the WCRF/AICR diet with gut microbiota and inflammation. These results need to be validated in additional prospective or interventional studies.
背景
世界癌症研究基金会和美国癌症研究所（WCRF/AICR）的饮食建议是否会影响肠道微生物群和炎症状态尚不清楚。我们在横断面研究中检查了对 WCRF/AICR 饮食的依从性评分与肠道微生物群和炎症之间的关系。
方法
对 151 名参与者（腺瘤 97 名，非腺瘤 54 名）的 7 天饮食记录计算 WCRF/AICR 饮食依从性评分。通过粪便样本的 16S rRNA 基因测序分析肠道微生物群。在有血液样本的 97 名结直肠腺瘤患者中评估血液（即 IL-6、IL-8、IgA、IgM 和 IgG）和粪便样本（即 FCP）中炎症生物标志物的水平。进行多变量线性回归分析，以检查个体和总饮食依从性评分与肠道微生物群和炎症生物标志物水平的关联。
结果
与低依从性者相比，依从性较高者的相对丰度较低：（= -0.041，95%：-0.073，-0.009），（= -0.035，95%：-0.067，-0.003）和未鉴定的属水平（= -0.029，95%：-0.055，-0.003）。植物性食物摄入量与增加的丰度呈正相关（= 0.013，95%：0.001，0.026）。限制快餐与丰富的（= 0.149，95%：0.040，0.257）和（= 0.149，95%：0.040，0.257）有关。限制含糖饮料与（= -0.155，95%：-0.292，-0.018）的丰度降低有关。植物性食物摄入（= -0.251，95%：-0.450，-0.052）和限制快餐（= -0.226，95%：-0.443，-0.008）与男性的 IgG 水平降低有关。限制饮酒与女性的 IL-6（= -7.095，95%：-11.286，-2.903）和 IL-8（= -7.965，95%：-14.700，-1.230）水平降低有关，但与男性的 IL-6（= 0.918，95%：0.161，1.675）水平升高有关。
结论
我们的研究结果支持对 WCRF/AICR 饮食的依从性与肠道微生物群和炎症之间的关联。这些结果需要在额外的前瞻性或干预性研究中得到验证。
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